| 引用本文: | 许同丽,刘钦弘,王寅初*,崔玉琳,李文军,秦松.肥胖影响下高血压与高血脂相关联的分子机制研究进展[J].中国现代应用药学,2024,41(4):545-555. |
| XU Tongli,LIU Qinhong,WANG Yinchu*,CUI Yulin,LI Wenjun,QIN Song.Research Progress in the Molecular Mechanism of the Relationship Between Hypertension and Hyperlipidemia Under the Influence of Obesity[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(4):545-555. |
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| 肥胖影响下高血压与高血脂相关联的分子机制研究进展 |
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许同丽1, 刘钦弘2, 王寅初*2,3,4,5, 崔玉琳3, 李文军3, 秦松3
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1.山东中医药大学青岛中医药科学院, 济南 250000;2.烟台大学药学院, 山东 烟台 264005;3.中国科学院烟台海岸带研究所, 山东 烟台 264003;4.国家基础学科公共科学数据中心, 北京 100190;5.中国科学院海洋大科学研究中心, 山东 青岛 266071
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| 摘要: |
| 过去几十年全球肥胖人数不断增多，并且仍然具有上升的趋势，与肥胖随之而来的是心脑血管患病风险的增加。研究发现，身体质量指数增加与一些心脑血管疾病的发生具有相关性。高血压、高血脂作为常见的慢性心血管疾病，受到肥胖影响尤为明显，引起了近年来学术界的广泛关注。不仅如此，肥胖影响下高血压与高血脂的发生是显著关联的，两者的协同作用还能够引发多种心脑血管疾病。目前关于三者相互作用机制的专门研究相对较少。因此，本文在分别总结肥胖影响高血压与高血脂分子机制的基础上，总结归纳肥胖影响下高血压与高血脂相关联的分子机制，指出共同作用分子，为未来心脑血管疾病的研究提供参考。 |
| 关键词: 肥胖 高血压 高血脂 关联 作用机制 |
| DOI：10.13748/j.cnki.issn1007-7693.20233283 |
| 分类号:R966 |
| 基金项目:国家重点研发计划项目(2018YFA0903000)；国家科技条件基础平台国家基础学科公共科学数据中心课题(NBSDC-DB-22) |
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| Research Progress in the Molecular Mechanism of the Relationship Between Hypertension and Hyperlipidemia Under the Influence of Obesity |
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XU Tongli1, LIU Qinhong2, WANG Yinchu*2,3,4,5, CUI Yulin3, LI Wenjun3, QIN Song3
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1.Qingdao College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250000, China;2.School of Pharmacy, Yantai University, Yantai 264005, China;3.Yantai Institute of Coastal Zone, Chinese Academy of Sciences Yantai 264003, China;4.National Public Science Data Center for Basic Disciplines, Beijing 100190, China;5.Marine Research Center of Chinese Academy of Sciences, Qingdao 266071, China
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| Abstract: |
| In the past few decades, the global obesity population has been increasing, and still has an upward trend. With obesity, the risk of cardiovascular and cerebrovascular diseases has increased. It’s found that an increase in body mass index is associated with the occurrence of some cardiovascular and cerebrovascular diseases Hypertension and hyperlipidemia, as common chronic cardiovascular diseases, are particularly affected by obesity, which has attracted extensive attention in recent years. Moreover, the occurrence of hypertension and hyperlipidemia under the influence of obesity is significantly related, and their synergy can also cause a variety of cardiovascular and cerebrovascular diseases. However, there is still less work to study these three factors at the same time. Therefore, on the basis of summarizing the molecular mechanisms of obesity affecting hypertension and hyperlipidemia, this paper summarizes the relevant molecular mechanisms of hypertension and hyperlipidemia under the influence of obesity, and points out the co-acting molecules, providing a reference for future research on cardiovascular and cerebrovascular diseases. |
| Key words: obesity hypertension hyperlipidemia relation action mechanism |
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