TRPV1在心血管疾病中的作用及相关中医药研究进展

吕红英; 侯明双; 贾冠军; 寇雨顺; 李梦瑶; 黎永祥; 徐静; 陈茜茜; 滕政杰; 伊琳*

引用本文:	吕红英,侯明双,贾冠军,寇雨顺,李梦瑶,黎永祥,徐静,陈茜茜,滕政杰,伊琳*.TRPV1在心血管疾病中的作用及相关中医药研究进展[J].中国现代应用药学,2024,41(4):556-566.
	LYU Hongying,HOU Mingshuang,JIA Guanjun,KOU Yushun,LI Mengyao,LI Yongxiang,XU Jing,CHEN Qianqian,TENG Zhengjie,YI Lin*.Role of TRPV1 in Cardiovascular Disease and the Related Progress of Traditional Chinese Medicine Research[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(4):556-566.

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TRPV1在心血管疾病中的作用及相关中医药研究进展
吕红英^1,2, 侯明双^1,2, 贾冠军^1,2, 寇雨顺^1,2, 李梦瑶^1,2, 黎永祥^1,2, 徐静^1,2, 陈茜茜^1,2, 滕政杰³, 伊琳*^1,2
1.甘肃中医药大学，兰州 730000;2.甘肃省中医药防治慢性疾病重点实验室，兰州 730000;3.甘肃中医药大学附属医院，兰州 730000

摘要:

瞬时受体电位香草素亚型1(transient receptor potential vanilloid-1，TRPV1)通道是瞬时受体电位亚家族的一种具有多种激活机制的非选择性配体门控阳离子通道，近年来大量研究发现TRPV1在高血压、动脉粥样硬化等心血管疾病领域扮演着重要角色。随着中药的深入研究，研究人员发现中药单体及其有效成分具有激活或抑制TRPV1通道的作用，在心血管疾病的研究中具有一定的潜力。本文综述TRPV1通道在心血管疾病中的作用以及中药基于TRPV1通道防治心血管疾病的研究进展，以期为防治心血管系统疾病提供新的思路。

关键词: 瞬时受体电位香草素亚型1 辣椒素受体心血管疾病中医药

DOI：10.13748/j.cnki.issn1007-7693.20230907

分类号:R969.3

基金项目:国家自然科学基金项目(82160842)；兰州市城关区科技局项目(2021SHFZ0017)；甘肃省科技计划联合科研基金一般项目(23JRRA1521)；甘肃省自然科学基金项目(20JR10RA368)

Role of TRPV1 in Cardiovascular Disease and the Related Progress of Traditional Chinese Medicine Research

LYU Hongying^1,2, HOU Mingshuang^1,2, JIA Guanjun^1,2, KOU Yushun^1,2, LI Mengyao^1,2, LI Yongxiang^1,2, XU Jing^1,2, CHEN Qianqian^1,2, TENG Zhengjie³, YI Lin*^1,2

1.Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China;2.Gansu Provincial Key Laboratory of TCM Prevention and Treatment of Chronic Diseases, Lanzhou 730000, China;3.Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

Abstract:

Transient receptor potential vanilloid-1(TRPV1) channel is a non-selective ligand-gated cationic channel with multiple activation mechanisms in the transient receptor potential subfamily. In recent years, a large number of studies have found that TRPV1 plays an important role in the field of cardiovascular diseases such as hypertension and atherosclerosis. With the in-depth study of traditional Chinese medicine, it has been found that Chinese medicine monomers and their active components can activate or inhibit TRPV1 channels, which has certain potential in the study of cardiovascular diseases. In this paper, the role of TRPV1 channel in cardiovascular diseases and the research progress of traditional Chinese medicine prevention and treatment of cardiovascular diseases based on TRPV1 channel are reviewed, in order to provide new ideas for prevention and treatment of cardiovascular system diseases.

Key words: transient receptor potential vanilloid-1 capsaicin receptor cardiovascular diseases traditional chinese medicine