| 引用本文: | 叶继锋,侯齐书,杨莲华,吴伟明.基于群体药动学原理对1例新生儿败血症合并脑膜炎的药学监护[J].中国现代应用药学,2019,36(20):2576-2579. |
| YE Jifeng,HOU Qishu,YANG Lianhua,WU Weiming.Pharmaceutical Care of A Neonate with Septicemia Complicated with Meningitis Based on Population Pharmacokinetics[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(20):2576-2579. |
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| 摘要: |
| 目的 为临床制定万古霉素个体化给药方案提供参考。方法 临床药师运用万古霉素群体药动学模型对1例新生儿败血症合并脑膜炎病例开展个体化给药方案调整和实施药学监护。结果 在基于治疗药物的监测和万古霉素群体药动学模型制定的万古霉素静脉注射联合脑室内注射的给药方案下，患儿感染得到有效控制，无不良反应发生。结论 临床药师应用群体药动学模型优化万古霉素抗感染治疗方案，协助临床医师制定个体化给药方案。 |
| 关键词: 万古霉素 群体药动学 新生儿 败血症 脑膜炎 脑室内注射 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.20.018 |
| 分类号:R969.3 |
| 基金项目:温州市公益性科技计划项目（Y20170688） |
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| Pharmaceutical Care of A Neonate with Septicemia Complicated with Meningitis Based on Population Pharmacokinetics |
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YE Jifeng, HOU Qishu, YANG Lianhua, WU Weiming
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The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China
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| Abstract: |
| OBJECTIVE To provide reference for physicians to establish individualized treatment of vancomycin. METHODS Clinical pharmacists applied the the population pharmacokinetic(PPK) model to adjust the dosage of vancomycin and to provide pharmaceutical care for a neonate with septicemia complicated with meningitis. RESULTS The infection in this neonate was effectively controlled following intravenous combined with intraventricular injection of vancomycin based on therapeutic drug monitoring and PPK model, and there were no vancomycin-caused adverse reactions. CONCLUSION Pharmacist can optimize the antiinfective treatment of vancomycin and help physicians to eatabilish the individualized treatment with PPK model. |
| Key words: vancomycin population pharmacokinetics neonate septicemia meningitis intraventricular injection |
