金属离子在阿尔兹海默症发病机制中的作用

李传盛; 魏文华; 沈正荣; 黄文海<sup>*</sup>

引用本文:	李传盛,魏文华,沈正荣,黄文海.金属离子在阿尔兹海默症发病机制中的作用[J].中国现代应用药学,2017,34(3):470-474.
	LI Chuansheng,WEI Wenhua,SHEN Zhengrong,HUANG Wenhai.Role of Metal Ions in the Pathogenesis of Alzheimer's Disease[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(3):470-474.

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金属离子在阿尔兹海默症发病机制中的作用
李传盛¹, 魏文华^1,2, 沈正荣¹, 黄文海¹
1.浙江省医学科学院药物研究所, 杭州 310013;2.杭州医学院, 杭州 310053

摘要:

阿尔兹海默症（Alzheimer’s disease，AD）又称原发性老年痴呆症，是一种中枢神经系统退行性疾病，主要表现为渐进性记忆障碍、认知功能障碍、人格改变及语言障碍等神经精神症状。由于其发病机制复杂，尽管人们已对该病研究百余年，但关于AD发病的具体机制仍不十分清楚。脑内金属离子失衡，加速β淀粉样蛋白沉积和Tau蛋白聚集，与AD的发生发展密切相关。本文对金属离子（如锌、铜、铁）在AD发病机制中的作用进行概述。

关键词: 金属离子阿尔兹海默症发病机制

DOI：10.13748/j.cnki.issn1007-7693.2017.03.038

分类号:

基金项目:国家自然科学基金（81302646）；浙江省科技计划项目（2015F50015）

Role of Metal Ions in the Pathogenesis of Alzheimer's Disease

LI Chuansheng¹, WEI Wenhua^1,2, SHEN Zhengrong¹, HUANG Wenhai¹

1.Institute of Materia Medica, Zhejiang Academy of Medical Science, Hangzhou 310013, China;2.Hangzhou Medical College, Hangzhou 310053, China

Abstract:

Alzheimer's disease (AD), also known as primary dementia, is a complex neurodegenerative disorder, with patients develop neuropsychiatric symptoms of progressive memory impairment, cognitive dysfunction, personality change and language disorders, etc. Due to the complexity of its pathogenesis, it is not really clear what the mechanism related to AD works up to now. The aberrant of metal homeostasis in the brain may be one of the main reasons that induce amyloid β-protein deposition and Tau protein aggregation, and accelerate the development of AD. In this paper, the role of metal ions, such as zinc, copper and iron in AD pathogenesis is overviewed.

Key words: metal ions Alzheimer's disease pathogenesis