| 引用本文: | 茹仁萍,孙宇,李松龙,赵亚.甘草酸磷脂复合物自乳化制剂处方筛选[J].中国现代应用药学,2016,33(1):63-68. |
| RU Renping,SUN Yu,LI Songlong,ZHAO Ya.Preparation of Glycyrrhizic Acid Phospholipid Complex Self-emulsifying Drug Delivery System[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(1):63-68. |
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| 摘要: |
| 目的 对甘草酸磷脂复合物自乳化制剂(self-emulsifying drug delivery system，SEDDS)进行处方筛选及制备。方法 用溶解性实验，处方配伍实验和伪三元相图等方法进行甘草酸磷脂复合物SEDDS制备研究，优选乳化剂，油相和助乳化剂；确定处方组分比例，考察处方自乳化效率。结果 最佳甘草酸磷脂复合物SEDDS处方为Labrafil 1944 cs∶Cremophor EL35∶Transcutol HP =45∶40∶15，处方载药量为27.3%；该处方能形成具有乳光透明乳液，粒度分布均匀。结论 该方法可成功制备甘草酸磷脂复合物自乳化制剂。 |
| 关键词: 甘草酸磷脂复合物 自乳化 伪三元相图 |
| DOI： |
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| 基金项目:浙江省中医药管理局重点项目(2009ZA014) |
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| Preparation of Glycyrrhizic Acid Phospholipid Complex Self-emulsifying Drug Delivery System |
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RU Renping, SUN Yu, LI Songlong, ZHAO Ya
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Department of Pharmacy, Hangzhou Xixi Hospital, Hangzhou 310023, China
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| Abstract: |
| OBJECTIVE To prepare glycyrrhizic acid phopholipid compelx self-emulsifying formulation(SEDDS). METHODS Solubility studies, compatibility study and pseudo-ternary phase diagram were used to study the preparation of glycyrrhizic acid phospholipid complex SEDDS. RESLUTS The optimized formulation of glycyrrhizic acid phospholipid complex self-emulsifying preparation was Labrafil 1944cs∶Cremophor EL35∶Transcutol HP=45∶40∶15, with the drug located 27.3%. The obtained emulsion showed even and nano grade particle size with transparent appearance. CONCLUSION Self-emulsifying drug delivery system for glycyrrhizic acid phospholipid complex has been prepared. |
| Key words: glycyrrhizic acid phospholipid complex self-emulsifying pseudo ternary phase diagram |
