| 引用本文: | 茹仁萍,孙宇,方进,赵亚.甘草酸磷脂复合物自乳化浓缩液的稳定性考察[J].中国现代应用药学,2015,32(1):39-42. |
| RU Renping,SUN Yu,FANG Jin,ZHAO Ya.Stability of Glycyrrhizic Acid Phospholipid Complex Self-emulsifying Concentrated Solution[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(1):39-42. |
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| 摘要: |
| 目的 考察甘草酸磷脂复合物自乳化浓缩液的稳定性。方法 通过低温试验(4 ℃)，冷热循环试验(4 ℃，37 ℃)和长期试验，观察自乳化时间及乳化效果，并用HPLC测定不同条件下甘草酸的含量。结果 经低温存放7 d、冷热循环7 d、常温留样6个月，自乳化浓缩液均为澄清透明溶液，无药物析出，所考察指标未见明显改变。结论 甘草酸磷脂复合物自乳化浓缩液澄清透明，性质稳定。 |
| 关键词: 甘草酸磷脂复合物 自乳化 稳定性 高效液相色谱法 |
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| 基金项目:浙江省中医药管理局重点项目(2009ZA014) |
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| Stability of Glycyrrhizic Acid Phospholipid Complex Self-emulsifying Concentrated Solution |
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RU Renping, SUN Yu, FANG Jin, ZHAO Ya
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Department of Pharmacy, Hangzhou Xixi Hospital, Hangzhou 310023, China
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| Abstract: |
| OBJECTIVE To investigate the stability of glycyrrhizic acid phospholipid complex self-emulsifying concentrated solution. METHODS Low temperature test(4 ℃), temperature cycling test(4 ℃, 37 ℃) and long-time test were used to study the emulsification time and emulsifying effect. The content of the samples were evaluated by HPLC. RESLUTS Items of the samples were according with the quality standard by cold testing of 7 d, temperature cycling testing of 7 d, long-time testing for 6 months. CONCLUSION Glycyrrhizia acid phospholipid complex self-emulsifying concentrated solution is clear and transparent with stable quality. |
| Key words: glycyrrhizic acid phospholipid complex self-emulsifying stability HPLC |
