| 引用本文: | 赵亚,李松龙,茹仁萍,梅笑冰,王琦.甘草酸磷脂复合物自乳化胶囊与肠溶胶囊的药动学比较[J].中国现代应用药学,2014,31(3):310-312. |
| ZHAO Ya,LI Songlong,RU Renping,MEI Xiaobing,WANG Qi.Comparison of the Pharmacokinetics Between Glycyrrhizic Acid Phospholipid Complex Self Emulsifying Capsule and Enteric Coated Capsule[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(3):310-312. |
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| 摘要: |
| 目的 以市售甘草酸二铵肠溶胶囊为参比制剂，考察自制甘草酸磷脂复合物自乳化胶囊在Beagle犬体内的相对生物利用度。方法 Beagle犬6只，自身交叉对照、单剂量灌胃甘草酸磷脂复合物自乳化胶囊或市售肠溶胶囊。采用HPLC测定血浆中的甘草酸浓度，DAS 2.0程序拟合药代动力学数据。结果 参比制剂和受试制剂主要的药动学参数：Tmax分别为(6.00±0.000)h，(2.917±0.585)h；Cmax分别为(12.756±1.075)mg·L-1，(17.751±1.604)mg·L-1；AUC0-t分别为(150.894±22.850)mg·h·L-1，(211.196±40.880)mg·h·L-1；AUC0-∞分别为(159.39±21.862)mg·h·L-1，(221.287±42.164)mg·h·L-1，甘草酸磷脂复合物自乳化制剂相对生物利用度(F%)为139.76%。结论 Beagle犬体内甘草酸的药动学规律均符合一级吸收二室模型，与市售胶囊剂相比，自乳化制剂的Cmax、AUC0-t，AUC0-∞均高于肠溶胶囊，表明自乳化制剂能显著提高药物的生物利用度，初步达到了设计要求。 |
| 关键词: 甘草酸磷脂复合物 自乳化制剂 高效液相色谱 药动学 |
| DOI： |
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| 基金项目:浙江省中医药管理局重点项目(2009ZA014) |
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| Comparison of the Pharmacokinetics Between Glycyrrhizic Acid Phospholipid Complex Self Emulsifying Capsule and Enteric Coated Capsule |
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ZHAO Ya, LI Songlong, RU Renping, MEI Xiaobing, WANG Qi
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Department of Pharmacy, Hangzhou Xixi Hospital, Hangzhou 310023, China
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| Abstract: |
| OBJECTIVE To compare the pharmacokinetics between glycyrrhizic acid phospholipid complex self emulsifying preparation(T) and glycyrrhizic acid diammonium enteric coated capsule(R) in dogs. METHODS Six Beagle dogs were given orally T and R, with a single dose of 50 mg·kg-1 glycyrrhizic acid in self crossover study. The plasma concentration of glycyrrhizic acid was assayed by HPLC and the pharmacokinetic parameters were calculated with DAS2.0 program. RESULTS Tmax for R and T were (6.00±0.000)h and (2.917±0.585)h; Cmax for R and T were (12.756±1.075)mg·L-1 and (17.751±1.604)mg·L-1, respectively; AUC0-t were (150.894±22.850)mg·h·L-1 and (211.196±40.880)mg·h·L-1; AUC0-∞ were (159.39±21.862)mg·h·L-1 and (221.287±42.164)mg·h·L-1; the relative bioavailability of T was 139.76%. CONCLUSIONS The pharmacokinetics of glycyrrhizic acid in dogs accorded with the two compartment models and with the first-order absorption after T or R administration orally, Cmax, AUC0-t and AUC0-∞ of T were all higher than those of R, and T had a higher bioavailability, which reached the object of this task. |
| Key words: glycyrrhizic acid phospholipid complex self emulsifying preparation HPLC pharmacokinetics |
