| 引用本文: | 余璇,王萌,任晓亮,张德芹.基于水溶性杯芳烃的超分子体系在药物传递中的应用[J].中国现代应用药学,2022,39(9):1226-1234. |
| YU Xuan,WANG Meng,REN Xiaoliang,ZHANG Deqin.Application of Water-soluble Calixarene-based Supramolecular Macrocycles in Drug Delivery[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(9):1226-1234. |
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| 基于水溶性杯芳烃的超分子体系在药物传递中的应用 |
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余璇1,2, 王萌1,2, 任晓亮3, 张德芹1,2
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1.天津中医药大学组方中药国家重点实验室, 天津 301617;2.天津中医药大学中医药研究院, 天津 301617;3.天津中医药大学中药学院, 天津 301617
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| 摘要: |
| 杯芳烃是第三代超分子大环主体，具有合成简单，易于功能化修饰，空腔大小可调控等优势，其与客体分子基于非共价键作用的结合具有改善疏水性药物溶解度，提高生物利用度，降低毒性和刺激性等作用。分子组装的特性赋予了杯芳烃在一定条件下形成不同形态纳米聚集体的能力，为药物传递提供了新的思路。本文基于超分子大环的2种核心作用，即主客体络合和分子组装，对水溶性杯芳烃构筑的药物传递系统进行介绍，综述了近10年来该类药物传递系统在改善难溶性药物溶解度，增加药物生物利用度、靶向性、减少不良反应发生率及其他方面的应用。 |
| 关键词: 杯芳烃 主客体作用 自组装 药物传递 纳米粒 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.09.018 |
| 分类号:R914.2 |
| 基金项目:国家自然科学基金项目(82074280) |
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| Application of Water-soluble Calixarene-based Supramolecular Macrocycles in Drug Delivery |
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YU Xuan1,2, WANG Meng1,2, REN Xiaoliang3, ZHANG Deqin1,2
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1.Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Component-based Chinese Medicine, Tianjin 301617, China;2.Tianjin University of Traditional Chinese Medicine, Research Institute of Traditional Chinese Medicine, Tianjin 301617, China;3.Tianjin University of Traditional Chinese Medicine, School of Chinese Materia Medica, Tianjin 301617, China
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| Abstract: |
| As the representative supramolecular macrocycles of third generation, calixarene has the advantages of simple synthesis, easy functional modification and adjustable cavity size. The noncovalent interactions of host and guest exhibited several advantages in improving solubility of hydrophobic drugs, improving bioavailability, and decreasing toxicity or irritation. The characteristics of molecular assembly supply the calixarene with the ability to form different nano aggregates, which provides a new idea for drug delivery. Based on the two core functions of supramolecular macrocycles, host guest complexation and molecular assembly, the review elaborates on the research progress of water-soluble calixarene-based drug delivery system with nano structures and the applications, et al, in improving the solubility, increasing the bioavailability and targeting of antitumor drugs, reducing the rate of adverse reaction, et al, in recent 10 years. |
| Key words: calixarene host-guest role self-assembly drug delivery nanoparticles |
