| 引用本文: | 应国红,邓颖,李玉兰,黄志强.GC测定注射用阿莫西林钠中残留的有机溶剂[J].中国现代应用药学,2010,27(8):738-741. |
| .Determination of Residual Organic Solvents in Amoxicillin Sodium for Injection by GC[J].Chin J Mod Appl Pharm(中国现代应用药学),2010,27(8):738-741. |
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| 摘要: |
| 目的 建立注射用阿莫西林钠有机溶剂残留量的测定方法。方法 采用顶空进样毛细管气相色谱法，色谱柱为DB-624毛细管柱(30 m×0.25 mm，1.4 μm)，柱温：40 ℃，顶空温度85 ℃，平衡时间：30 min，进样口温度：200 ℃，FID检测器温度：250 ℃，以正丙醇为内标，高纯氮气为载气，测定了注射用阿莫西林钠中7种有机溶剂的残留量。结果 各有机溶剂均能得到有效分离，在所考察的浓度范围内线性关系良好，r为0.999 0~0.999 8，平均回收率为91.3%~105.7%。结论 本方法灵敏、简便、结果准确，可用于注射用阿莫西林钠中残留溶剂的检测。 |
| 关键词: 注射用阿莫西林钠 顶空气相色谱法 残留溶剂 |
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| Determination of Residual Organic Solvents in Amoxicillin Sodium for Injection by GC |
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YING Guohong DENG Ying LI Yulan HUANG Zhiqiang
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| Abstract: |
| OBJECTIVE To establish a method for determination of residual organic solvents in amoxicillin sodium for injection. METHODS A DB-624 capillary column(30 m×0.25 mm, 1.4 μm) was used at 40 ℃, the headspace temperature was 85 ℃ and kept for 30 minutes, the temperature of inlets and FID detector were 200 ℃ and 250 ℃, propanol as internal standard, high purity nitrogen as the carry gas. RESULTS Seven residual organic solvents were completely separated and there were good linearies(r=0.999 0-0.999 8). The average recovery rate was in the range of 91.3%-105.7%. CONCLUSION The method proved to be sensitive, simple and accurate, and can be used for determination of residual organic solvents in amoxicillin sodium for injection. |
| Key words: amoxicillin sodium for injection headspace GC residual organic solvents |
