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| 摘要: |
| 目的 通过介绍体内各屏障高度表达的P糖蛋白外排作用对HIV-1蛋白酶抑制剂的影响，探讨如何通过有效调节P糖蛋白，优化对艾滋病患者的治疗。方法 查阅国外文献进行总结和归纳。结果 综述了P糖蛋白表达对HIV-1蛋白酶抑制剂在体内吸收、分布的影响。 结论 P糖蛋白一定程度地阻碍了HIV-1蛋白酶抑制剂在体内的吸收和分布，通过抑制P糖蛋白的活性，可以增加HIV-1蛋白酶抑制剂的化学疗效，未来艾滋病的治疗，P糖蛋白抑制剂的选择和使用将是一项艰巨的任务。 |
| 关键词: P糖蛋白 分布 屏障 |
| DOI： |
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| The Role of P-Glycoprotein Expression on Absorption and Distribution of HIV-1 Protease Inhibitors |
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YAO Yao HU Zhuohan
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| Abstract: |
| OBJECTIVE By introducing the efflux function of P-glycoprotein(P-gp), the way to optimize the treatment of HIV-1 infection by modulation of P-gp was discussed. METHODS Searching and summarizing literatures about HIV-1 protease inhibitor and P-gp. RESULTS The effect of P-gp expression for HIV-1 protease inhibitor absorption and distribution was summarized. CONCLUSION P-gp can hamper the absorption and distribution of HIV-1 protease inhibitor. The therapeutic effect of HIV-1 protease inhibitors can be improved by modulating P-gp properly, however, the selection and use of P-gp inhibitor will be an arduous mission in the future. |
| Key words: P-glycoprotein distribution barrier |
