| 引用本文: | 李亚飞,金利群,柳志强,郑裕国.吡嗪酰胺的研究进展[J].中国现代应用药学,2010,27(4):307-312. |
| .The Research Progress on Pyrazinamide[J].Chin J Mod Appl Pharm(中国现代应用药学),2010,27(4):307-312. |
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| 摘要: |
| 目的 介绍吡嗪酰胺的研究进展。方法 本文对吡嗪酰胺的化学合成法和微生物催化转化法进行了综述，并对两者进行了比较。同时，对吡嗪酰胺的应用也作了探讨。结果 与化学法生产吡嗪酰胺相比，微生物法催化转化2-氰基吡嗪生产吡嗪酰胺，具有反应条件温和，产物产率高和纯度高等优点。结论 吡嗪酰胺是一种重要的抗结核药物。由于在医药和化工方面的广泛应用，其研究越来越引起人们的重视。 |
| 关键词: 吡嗪酰胺 化学合成 微生物法 腈水合酶 2-氰基吡嗪 |
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| The Research Progress on Pyrazinamide |
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LI Yafei JIN Liqun LIU Zhiqiang ZHENG Yuguo*
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| Abstract: |
| OBJECTIVE To review the progress of pyrazinamide. METHODS This paper provides an overview about the chemical synthesis and biotransformation preparation of pyrazinamide, the advantages of the two methods and the application of pyrazinamide. RESULTS Compared with the chemical method, the microbial preparation of pyrazinamide with the substrate of 2-cyanopyrazine has the more advantages on the friendly reaction conditions, the high output and the purity. CONCLUSION Pyrazinamide is an important anti-tuberculous agent. It is receiving considerable attention for its application in pharmaceutical and chemical industry. |
| Key words: pyrazinamide chemical synthesis microbial method nitrile hydratase 2-cyanopyrazine |
