| 引用本文: | 黄洋,贾晓斌,陈斌,王晋艳.适合挤出滚圆的物料性质与微丸成型性预测指标研究探讨[J].中国现代应用药学,2011,28(1):35-39. |
| HUANG Yang,JIA Xiaobin,CHEN Bin,WANG Jinyan.Analysis of the Property of Material in the Extrusion-Spheronization and the Predictive Index[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(1):35-39. |
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| 摘要: |
| 目的 探讨适合以挤出滚圆法制备微丸的物料性质以及微丸成型性预测指标的建立。方法 综合国内外文献报道，探讨了物料中液体的饱和度和流动性、药物和辅料粉末的溶解性和保水性、处方的流变学性质参数(扭矩、储能模量和耗能模量、可恢复剪切和顺应性)与微丸成型性的相关性。结果 各性质和参数对挤出滚圆均有一定的影响，但是都不能够单独的预测处方是否可以制备成合格的微丸，同时各性质和参数之间存在着协同和交互作用。结论 建立一个能够预测微丸成型性的量化指标可能需要物料几个性质和参数的综合或者新的影响因素的发现。 |
| 关键词: 物料性质 软材 量化指标 微丸 挤出滚圆 |
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| 基金项目:江苏省中医药领军人才专项(2006)；国家中医药管理局中医药科学技术研究专项(06-07ZQ05)；江苏省中医药局中医药科技技术研究专项(LZ09061) |
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| Analysis of the Property of Material in the Extrusion-Spheronization and the Predictive Index |
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HUANG Yang1,2, JIA Xiaobin1, CHEN Bin1,2, WANG Jinyan1,2
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1.Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;2.School of Pharmacy, Jiangsu University, Zhenjiang 212013, China
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| Abstract: |
| OBJECTIVE To discuss the relativity between material properties and pelletization by the process of extrusion-spheronization. METHODS Make a summary of both national and overseas papers about the suitability of the wet mass used to produce pellets by extrusion-spheronization. This paper is to determine the relevance between the property of wet powder masses (such as the fluid saturation and mobility, the solubility and the ability of holding water of drugs and accessories, the rheological properties) and pelletization. RESULTS Although many properties are relative to the process of extrusion-spheronization, none of them can predict producing qualified pellet. CONCLUSION This paper gives consultation to the further research and exploitation of the material fit for the process of extrusion-spheronization. |
| Key words: material properties wet powder masses quantitative index pellets extrusion-spheronization |
