| 引用本文: | 徐立,李兆波,王冲,张红.外周5-羟色胺系统与糖尿病及其并发症防治关系的研究进展[J].中国现代应用药学,2020,37(22):2803-2809. |
| XU Li,LI Zhaobo,WANG Chong,ZHANG Hong.Research Progress on the Relationship of Peripheral 5-Hydroxytryptamine System and Diabetes or Its Complications[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(22):2803-2809. |
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| 摘要: |
| 糖尿病及相关并发症严重威胁人类的健康，但由于其发病机制未被阐明，阻碍了抗糖尿病药物的开发与推广。临床和动物实验结果表明5-羟色胺（5-hydroxytryptamine，5-HT）和糖尿病的发生、发展有紧密的关联，随着研究的不断深入，外周5-HT系统显示出作为治愈糖尿病重要靶点的潜力。本文首先对外周5-HT在糖尿病及其并发症发生和发展过程中的作用进行阐述，接着对5-HT调节糖尿病的机制进行探讨，随后对与糖尿病并发症相关的5-HT受体进行系统的总结，最后对如何利用药物通过5-HT系统防治糖尿病提出展望。 |
| 关键词: 外周5-羟色胺 五羟色胺受体 糖尿病 糖尿病并发症 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.22.021 |
| 分类号:R969.3 |
| 基金项目:陕西省教育厅科学研究计划项目（19JK0243，17JK0218） |
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| Research Progress on the Relationship of Peripheral 5-Hydroxytryptamine System and Diabetes or Its Complications |
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XU Li, LI Zhaobo, WANG Chong, ZHANG Hong
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Shaanxi University of Chinese Medicine, Medical Experiment Center, Xianyang 712046, China
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| Abstract: |
| Diabetes mellitus and its complications become serious threat to human health. Due to the ambiguous mechanism of diabetes pathogenesis, the development and promotion of anti-diabetes drugs have greatly hindered. Clinical and animal experimental results suggest a close association between 5-hydroxytryptamine(5-HT) and the occurrence and development of diabetes. With the deepening of research, the peripheral 5-HT system has shown its potential as an important target for curing diabetes. First of all, peripheral 5-HT in the occurrence and development of diabetes and its complications is described, and then the mechanism of 5-HT regulating diabetes is discussed, then 5-HT receptors which associated with diabetes complications are systematically summarized, finally, the prospect of how to use drugs to prevent and cure diabetes through 5-HT system is put forward. |
| Key words: peripheral 5-HT 5-HT receptor diabetes diabetes complication |
