| 引用本文: | 梅紫薇,骆松梅,徐艳艳,朱延焱,张霞燕,傅军霞,田伟强.黄连总生物碱胃内漂浮缓释片处方组成的研究[J].中国现代应用药学,2020,37(20):2476-2480. |
| MEI Ziwei,LUO Songmei,XU Yanyan,ZHU Yanyan,ZHANG Xiayan,FU Junxia,TIAN Weiqiang.Study on the Formula Composition of Total Alkaloids of Coptis Chinensis Intragastric Floating Sustained Release Tablets[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(20):2476-2480. |
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| 摘要: |
| 目的 研究黄连总生物碱胃内漂浮缓释片的处方组成及影响因素。方法 以体外释放度为指标，筛选黄连总生物碱胃内漂浮缓释片的处方组成。采用单因素试验法，考察处方中羟丙甲纤维素（hydroxypropyl methylcellulose，HPMC）、海藻酸钠、碳酸氢钠3个因素对其体外释放度的影响。结果 黄连总生物碱胃内漂浮缓释片较优的处方组成为HPMC 13.4%，海藻酸钠26.6%，硬脂酸镁5.4%，硬脂酸42.0%，碳酸氢钠10.6%，HPMC与碳酸氢钠的用量显著影响黄连总生物碱胃内漂浮缓释片的体外释放度。结论 HPMC与海藻酸钠以1：2配伍使用作为片剂亲水凝胶骨架时，其体外释放度良好，且两者具有交互作用。 |
| 关键词: 黄连总生物碱 胃内漂浮 体外释放 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.20.008 |
| 分类号:R943 |
| 基金项目:浙江省中医药科技计划项目（2019ZQ047，2013ZB148）；丽水市科技计划项目（2016GYX40） |
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| Study on the Formula Composition of Total Alkaloids of Coptis Chinensis Intragastric Floating Sustained Release Tablets |
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MEI Ziwei, LUO Songmei, XU Yanyan, ZHU Yanyan, ZHANG Xiayan, FU Junxia, TIAN Weiqiang
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Lishui Municipal Central Hospital, Lishui 323000, China
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| Abstract: |
| OBJECTIVE To study the prescription composition and influencing factors of total alkaloids of Coptis chinensis intragastric floating sustained release tablets. METHODS The in vitro release of total alkaloids from Coptis chinensis was used as an index to screen the prescription composition of the sustained release tablets. The effects of hydroxypropyl methylcellulose(HPMC), sodium alginate and sodium bicarbonate on the in vitro release of the tablets were investigated by single factor test. RESULTS The optimal formulation of total alkaloids of Coptis chinensis intragastric floating sustained release tablets was HPMC 13.4%, sodium alginate 26.6%, magnesium stearate 5.4%, stearic acid 42.0%, NaHCO3 10.6%. The dosage of HPMC and sodium bicarbonate significantly affected the in vitro release of total alkaloids of Coptis chinensis intragastric floating sustained release tablets. CONCLUSION HPMC and sodium alginate combined with the ratio of 1:2 as tablet hydrophilic gel skeleton have good release in vitro, and they interact with each other. |
| Key words: total alkaloids of Coptis chinensis intragastric floating in vitro release |
