| 引用本文: | 王仁杰,王凯玉,过科家,卜晶,黄丹芍,赵宇,陈盛君.Box-Behnken响应面法优化高良姜挥发油的包合工艺研究[J].中国现代应用药学,2020,37(19):2356-2361. |
| WANG Renjie,WANG Kaiyu,GUO Kejia,BU Jing,HUANG Danshao,ZHAO Yu,CHEN Shengjun.Optimization for Inclusion Process of Alpinia Officinarum Hance Volatile Oil by Box-Behnken Response Surface Methodology[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(19):2356-2361. |
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| 摘要: |
| 目的 优化胶体磨法制备高良姜挥发油β-环糊精（β-cyclodextrin，β-CD）包合物的工艺。方法 在单因素试验基础上采用Box-Behnken响应面法，以包合物得率和包合率为评价指标，考察β-CD与高良姜挥发油的比例、水与β-CD的比例以及包合时间对包合工艺的影响；通过红外光谱法和显微影像法初步验证高良姜挥发油β-CD包合物的生成。结果 高良姜挥发油的最佳包合工艺为β-CD与高良姜挥发油的比例为10∶1，水与β-CD的比例为5∶1，包合时间为45 min。结论 胶体磨法包合高良姜挥发油合理、可行。 |
| 关键词: 高良姜挥发油 β-环糊精 胶体磨 包合工艺 响应面优化 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.19.010 |
| 分类号:R943 |
| 基金项目:工信部智能制造综合标准化与新模式应用项目 |
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| Optimization for Inclusion Process of Alpinia Officinarum Hance Volatile Oil by Box-Behnken Response Surface Methodology |
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WANG Renjie, WANG Kaiyu, GUO Kejia, BU Jing, HUANG Danshao, ZHAO Yu, CHEN Shengjun
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Jiangyin Tianjiang Pharmaceutical Co., Ltd., Jiangyin 214434, China
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| Abstract: |
| OBJECTIVE To optimize the preparation process of Alpinia officinarum Hance volatile oil wrapped with b-cyclodextrin(b-CD) using the colloid mill method. METHODS With yield of inclusion compound and inclusion rate as evaluation indexes, the single factor test combining Box-Behnken response surface methodology was used to study the effects of the ratio of b-CD to Alpinia officinarum Hance volatile oil, the ratio of water to b-CD, and inclusion time on the inclusion process. Inclusion complexes were verified by IR and microscopic image. RESULTS The optimized parameters of inclusion were as follows:the ratio of b-CD to Alpinia officinarum Hance volatile oil was 10:1, the ratio of water to b-CD was 5:1, and the inclusion time was 45 min. CONCLUSION The inclusion of Alpinia officinarum Hance volatile oil by colloid mill is reasonable and feasible. |
| Key words: Alpinia officinarum Hance volatile oil β-cyclodextrin colloid mill inclusion process response surface optimization |
