中药成分通过调节PI3K/AKT信号通路在前列腺癌治疗中的研究进展

罗佳承; 阮豪南; 王露露; 张晶<sup>*</sup>

引用本文:	罗佳承,阮豪南,王露露,张晶.中药成分通过调节PI3K/AKT信号通路在前列腺癌治疗中的研究进展[J].中国现代应用药学,2021,38(9):1148-1152.
	LUO Jiacheng,RUAN Haonan,WANG Lulu,ZHANG Jing.Research Progress of Traditional Chinese Medicine Ingredients in the Treatment of Prostate Cancer by Regulating PI3K/AKT Signaling Pathway[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(9):1148-1152.

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中药成分通过调节PI3K/AKT信号通路在前列腺癌治疗中的研究进展
罗佳承¹, 阮豪南¹, 王露露², 张晶^1,2
1.吉林农业大学中药材学院, 长春 130118;2.长春科技学院医药学院, 长春 130000

摘要:

前列腺癌已成为世界范围内男性最常见的癌症之一。在临床中主要通过手术切除治疗、放射治疗和药物治疗，但在治疗的同时会产生一定的不良反应。近年来中药成分在治疗缓解癌症方面具有明显疗效，且不良反应相对较少。PI3K/AKT信号通路是癌症中最经典的通路之一，其参与肿瘤的增殖、细胞周期运行和迁移侵袭等过程。本文总结近年来国内外学者中药成分在PI3K/AKT信号通路中对前列腺癌治疗保护作用，旨在为利用中药成分及药物联用等方式治疗癌症提供新思路和治疗策略提供依据。

关键词: 前列腺癌 PI3K/AKT 中药成分

DOI：10.13748/j.cnki.issn1007-7693.2021.09.023

分类号:R285.6

基金项目:吉林省科技发展计划项目（20200404023YY）

Research Progress of Traditional Chinese Medicine Ingredients in the Treatment of Prostate Cancer by Regulating PI3K/AKT Signaling Pathway

LUO Jiacheng¹, RUAN Haonan¹, WANG Lulu², ZHANG Jing^1,2

1.College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China;2.School of Medicine, Changchun University of Science and Technology, Changchun 130000, China

Abstract:

Prostate cancer has become one of the most common cancers in men worldwide. In clinical practice, it is mainly through surgical resection treatment, radiation treatment and drug treatment, but it will produce side effects at the same time. In recent years, traditional Chinese medicine ingredients have obvious curative effects in the treatment of cancer, and relatively few side effects. PI3K/AKT signaling pathway is one of the most classical pathways in cancer, and it is involved in tumor proliferation, cell cycle operation, and migration and invasion. This article summarizes the protective effects of traditional Chinese medicine ingredients in the PI3K/AKT signaling pathway on prostate cancer treatment in recent years by domestic and foreign scholars, aim to provide a basis for the use of Chinese medicine ingredients and drug combination to treat cancer by providing new ideas and treatment strategies.

Key words: prostate cancer PI3K/AKT traditional Chinese medicine ingredients