| 引用本文: | 王信,马传江,杨培民,曹广尚,郭功玲,李健,辛义周.白花蛇舌草抗炎、抗肿瘤作用研究进展[J].中国现代应用药学,2020,37(19):2420-2427. |
| WANG Xin,MA Chuanjiang,YANG Peimin,CAO Guangshang,GUO Gongling,LI Jian,XIN Yizhou.Research Progress of Anti-inflammatory and Anti-tumor Effects of Hedyotis Diffusa Willd.[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(19):2420-2427. |
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| 摘要: |
| 慢性炎症与肿瘤的发生、发展、侵袭、转移等密切相关，清热解毒中药白花蛇舌草兼具抗炎、抗肿瘤作用，在临床上常用于各种炎症、肿瘤的预防与治疗。白花蛇舌草抗炎机制研究主要涉及NF-kB、MAPK、5-LOX等信号通路，抗肿瘤研究主要为抗肠癌、抗肺癌、抗肝癌、抗乳腺癌、抗胃癌等，机制涉及PI3K/AKT、TGF-β/Smad、MAPK、STAT3等信号通路，并可能通过NF-kB、MAPK、VEGF等途径在“炎-癌”转化过程中发挥重要作用。本文综述白花蛇舌草抗炎、抗肿瘤及干预“炎-癌”转化作用，为其进一步研究提供参考。 |
| 关键词: 炎-癌转化 白花蛇舌草 抗炎 抗肿瘤 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.19.022 |
| 分类号:R285 |
| 基金项目:国家自然科学基金项目（81773950）；山东省中医药科技发展计划项目（2019-1057） |
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| Research Progress of Anti-inflammatory and Anti-tumor Effects of Hedyotis Diffusa Willd. |
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WANG Xin, MA Chuanjiang, YANG Peimin, CAO Guangshang, GUO Gongling, LI Jian, XIN Yizhou
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Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Grade Three Laboratory of Traditional Chinese Medicine Preparation of State Administration of Traditional Chinese Medicine, Jinan 250011, China
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| Abstract: |
| Chronic inflammation is closely related to the occurrence, development, invasion and metastasis of tumors. Hedyotis diffusa Willd. has both anti-inflammatory and anti-tumor effects and is often used to prevent and treat various kinds of inflammation and tumors. The anti-inflammatory mechanism of Hedyotis diffusa Willd. is related to NF-κB, MAPK, 5-LOX and other signaling pathways and the anti-tumor effects include anti-colon cancer, anti-lung cancer, anti-liver cancer, anti-breast cancer, anti-gastric cancer, etc and anti-tumor mechanisms include signaling pathways such as PI3K/AKT, TGF-/Smad, MAPK, STAT3. Hedyotis diffusa Willd. plays an important role in the process of "inflammation-cancer" transformation through NF-κB, MAPK, VEGF and so on. This study provides a reference for the further research and development of the anti-inflammatory, anti-tumor properties and intervention on "inflammation-cancer" transformation of Hedyotis diffusa Willd. |
| Key words: inflammation-cancer transformation Hedyotis diffusa Willd. anti-inflammatory anti-tumor |
