| 引用本文: | 张玲希,张信岳,谷丽丽,鲁佳琪,李钦.阿尔茨海默病斑马鱼模型的研究现状及其应用[J].中国现代应用药学,2020,37(9):1145-1152. |
| ZHANG Lingxi,ZHANG Xinyue,GU Lili,LU Jiaqi,LI Qin.Application of Zebrafish Model in the Study of Alzheimer's Disease[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(9):1145-1152. |
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| 摘要: |
| 斑马鱼作为一种新兴的脊椎模式动物，被广泛用于多种疾病的研究，包括心血管疾病、中枢神经系统疾病、肾脏疾病等。斑马鱼与人类基因高度同源，具有体外受精、体外发育、个体透明等特点，基于斑马鱼构建的疾病模型极大地推动了相关领域的基础性研究。本文综述了近年来运用斑马鱼构建的阿尔茨海默病相关模型的研究现状及其应用，为斑马鱼在阿尔茨海默病新药开发研究中的应用提供新的思路。 |
| 关键词: 斑马鱼 模式动物 阿尔茨海默病 生物学特性 3R原则 应用 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.09.022 |
| 分类号:R965.1 |
| 基金项目:浙江省科技计划项目（2017C37162）；浙江省神经精神疾病药物研究重点实验室资助项目（2019E10021） |
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| Application of Zebrafish Model in the Study of Alzheimer's Disease |
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ZHANG Lingxi, ZHANG Xinyue, GU Lili, LU Jiaqi, LI Qin
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Department of Pharmacology, Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310000, China
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| Abstract: |
| Zebrafish(Danio rerio), as an emerging vertebrate model animal, is widely used in the research of various diseases, such as cardiovascular diseases, central nervous system diseases, kidney diseases and so on. Zebrafish's genes are highly homologous with human's. What's more, zebrafish is featuring in vitro fertilization, in vitro development in embryonic period and body transparency, etc. The models based on zebrafish has greatly promoted the basic research in the medical field. This review present the research progression in Alzheimer's disease(AD) and applications of the zebrafish models of AD in recent years. New ideas for the applications of zebrafish in the development and research of new drugs for AD are also provided. |
| Key words: zebrafish model organism Alzheimer's disease biological characteristics 3R principles applications |
