磷霉素抗菌活性及临床应用研究进展

刘云宁; 李小凤; 姜爱雯; 刘晓明

引用本文:	刘云宁,李小凤,姜爱雯,刘晓明.磷霉素抗菌活性及临床应用研究进展[J].中国现代应用药学,2020,37(10):1269-1275.
	LIU Yunning,LI Xiaofeng,JIANG Aiwen,LIU Xiaoming.Research Progress of Antibacterial Activity and Application of the Fosfomycin[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(10):1269-1275.

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磷霉素抗菌活性及临床应用研究进展
刘云宁¹, 李小凤², 姜爱雯¹, 刘晓明¹
1.河北北方学院附属第一医院, 药学部, 河北张家口 075000;2.河北北方学院附属第一医院, 微生物科, 河北张家口 075000

摘要:

近年来，多重耐药菌、泛耐药菌，甚至全耐药菌感染不断出现，给临床感染疾病的诊治带来严峻挑战。磷霉素因其独特的抗菌机制，在临床抗感染治疗中日益受到重视，多项研究证实磷霉素对耐药菌具有良好的抗菌活性。本文就磷霉素的抗菌机制、抗菌活性、耐药机制及临床应用进行综述。

关键词: 磷霉素抗菌作用机制抗菌活性耐药机制临床应用

DOI：10.13748/j.cnki.issn1007-7693.2020.10.022

分类号:R978.1

基金项目:河北省2019年度医学科学研究课题计划（20190916）

Research Progress of Antibacterial Activity and Application of the Fosfomycin

LIU Yunning¹, LI Xiaofeng², JIANG Aiwen¹, LIU Xiaoming¹

1.The First Affiliated Hospital of Hebei North University, Department of Pharmacy, Zhangjiakou 075000, China;2.The First Affiliated Hospital of Hebei North University, Microbiology, Zhangjiakou 075000, China

Abstract:

In recent years, multiple drug-resistant bacteria, extensively drug-resistant bacteria, and even pan drug-resistant infections have appeared continuously, which has brought serious challenges to the diagnosis and treatment of clinical infections. Fosfomycin has a unique antibacterial mechanism, it is highly effective in the treatment of multidrug-resistant microorganisms. This review focuses on the latest progress in the antibacterial mechanism, antimicrobial activity, resistance mechanism, clinical application of fosfomycin.

Key words: fosfomycin antibacterial mechanism antimicrobial activity resistant mechanism clinical application