亚精胺改善年龄相关认知障碍的研究进展

刘婷; 张蕊; 吴粉毅; 陈菲; 李振玉; 乔成栋<sup>*</sup>

引用本文:	刘婷,张蕊,吴粉毅,陈菲,李振玉,乔成栋.亚精胺改善年龄相关认知障碍的研究进展[J].中国现代应用药学,2020,37(12):1527-1531.
	LIU Ting,ZHANG Rui,WU Fenyi,CHEN Fei,LI Zhenyu,QIAO Chengdong.Research Progress of Spermidine Improve Age-related Cognitive Decline[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(12):1527-1531.

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亚精胺改善年龄相关认知障碍的研究进展
刘婷¹, 张蕊¹, 吴粉毅¹, 陈菲¹, 李振玉², 乔成栋¹
1.兰州大学第一医院, 老年病科, 兰州 730000;2.兰州大学第一医院, 药剂科, 兰州 730000

摘要:

认知能力下降是衰老的常见症状，与年龄相关的认知障碍被认为是正常或不可避免的，特别是60岁以上的人，记忆力更容易受到年龄的影响。随着人口预期寿命的延长，发生年龄相关认知障碍的人数也随之增加，因此认知障碍的改善或减缓受到了更多的关注。亚精胺是一种天然存在的多胺，涉及多种生理过程，包括神经保护、学习和记忆等，亚精胺可以通过诱导自噬及免疫调节维持突触可塑性，促进神经发生及巩固记忆，在神经退行性疾病的衰老生物模型中显示出有益效果。本文综述了亚精胺改善年龄相关认知障碍的现状及相关机制，以期为年龄相关的认知功能下降或其他神经退行性疾病的预防和治疗提供参考。

关键词: 亚精胺年龄相关认知障碍记忆力自噬免疫调节

DOI：10.13748/j.cnki.issn1007-7693.2020.12.023

分类号:R964

基金项目:

Research Progress of Spermidine Improve Age-related Cognitive Decline

LIU Ting¹, ZHANG Rui¹, WU Fenyi¹, CHEN Fei¹, LI Zhenyu², QIAO Chengdong¹

1.The First Hospital of Lanzhou University, Department of Geriatrics, Lanzhou 730000, China;2.The First Hospital of Lanzhou University, Department of Pharmacy, Lanzhou 730000, China

Abstract:

Cognitive decline is a common consequence of ageing, so age-related cognitive decline is considered normal or inevitable. For people over the age of 60, memory is more likely to be affected. With the extension of life expectancy, the number of people with age-related cognitive decline has also increased. Therefore, more attention has been paid to the improvement or mitigation of cognitive decline. Spermidine is a naturally polyamine, which involves many physiological processes, including neuroprotection learning and memory. Spermidine can maintain synaptic plasticity by inducing autophagy and immune regulation, which can promote neurogenesis and consolidate memory. It also has shown beneficial effects in aging biological models of neurodegenerative diseases. This paper reviews the current situation and relevant mechanism of spermidine in improving age-related cognitive decline, in order to provide reference for the prevention and treatment of age-related cognitive decline or other neurodegenerative diseases.

Key words: spermidine age-related cognitive decline memory autophagy immunoregulation