| 引用本文: | 刘顶鼎,杨菁,刘冬,王钧,杨许,曾贵荣.瓜子金及其组分治疗神经系统疾病的研究进展[J].中国现代应用药学,2020,37(8):1015-1018. |
| LIU Dingding,YANG Jing,LIU Dong,WANG Jun,YANG Xu,ZENG Guirong.Research Progress of Polygala Japonica Houtt. and Its Components in Treatment of Nervous System Diseases[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(8):1015-1018. |
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| 摘要: |
| 瓜子金为苗族民间常用草药，近年来瓜子金在神经系统中的药理研究取得了积极进展，发现瓜子金具有改善学习记忆、减轻认知障碍、抑制神经炎症、抑制神经细胞凋亡、抗抑郁、抗氧化等广泛的药理作用。因此，本文对瓜子金在神经系统疾病中的作用及机制进行综述，以期为开发瓜子金防治神经系统疾病提供理论依据。 |
| 关键词: 瓜子金 组分 阿尔茨海默病 帕金森病 抑郁症 脑缺血 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.08.026 |
| 分类号:R284.1 |
| 基金项目:国家自然科学基金项目（81860844）；贵州省中医药、民族医药科学技术研究专项（QZYY-2016-001）；贵州省教育厅青年科技人才成长项目（黔教合KY字[2016]185）；贵州省科技计划项目（黔科合基础[2016]1016、黔科合基础[2019]1038号）；贵州省苗医药重点实验室开放课题（黔苗医药K字[2017]007、黔苗医药K字[2017]031）；全国大学生创新创业训练项目[贵中医大创合字（2018）13号]；贵阳中医学院一流专业（中药学）项目[贵中医一流专业大创合字（2017）158号] |
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| Research Progress of Polygala Japonica Houtt. and Its Components in Treatment of Nervous System Diseases |
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LIU Dingding1, YANG Jing1, LIU Dong1, WANG Jun1, YANG Xu1, ZENG Guirong2
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1.Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China;2.Hunan Provincial Drug Safety Evaluation Research Center&Key Laboratory of New Drug Pharmacodynamics and Safety Evaluation of Hunan Province, Changsha 410331, China
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| Abstract: |
| Polygala japonica Houtt. is a common herbal medicine in Miao people. In recent years, the pharmacological research of Polygala japonica in the nervous system has made positive progress, and it has been found that Polygala japonica has a wide range of pharmacological effects, such as improve learning and memory, reduce cognitive impairment, inhibition of neuroinflammation, inhibition of neuronal apoptosis, anti-depressant, and anti-oxidation. Therefore, this paper reviews the role and mechanism of Polygala japonica in nervous system diseases, in order to provide a theoretical basis for the development of Polygala japonica to prevent and treat nervous system diseases. |
| Key words: Polygala japonica Houtt. components Alzheimer's disease Parkinson's disease depression cerebral ischemia |
