| 引用本文: | 李新华,闫一娇,林春艳,魏聖森.西替利嗪联合布地奈德对支气管哮喘患儿疗效及血清TGF-β1、MCP-1、SDF-1水平的影响[J].中国现代应用药学,2020,37(16):1998-2001. |
| LI Xinhua,YAN Yijiao,LIN Chunyan,WEI Shengsen.Efficacy of Cetirizine Combined with Budesonide on Children with Bronchial Asthma and its Effects on Levels of Serum TGF-β1, MCP-1 and SDF-1[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(16):1998-2001. |
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| 摘要: |
| 目的 研究西替利嗪联合布地奈德（budesonide，BUN）对支气管哮喘患儿治疗效果及血清转化生长因子β1（TGF-β1）、单核细胞趋化蛋白-1（MCP-1）、基质细胞衍生因子-1（SDF-1）水平的影响。方法 将94例急性发作期哮喘患儿随机均分为观察组（西替利嗪联合BUN，n=47）和对照组（BUN，n=47）进行治疗，疗程7 d，比较2组治疗效果、临床症状、肺功能指标及血清TGF-β1、MCP-1、SDF-1水平变化。结果 观察组和对照组治疗有效率分别为95.74%和82.98%（P<0.05）；观察组咳嗽、憋喘症状及哮鸣音、湿罗音等体征消失时间少于对照组（P<0.05）；治疗后，2组患儿第1秒用力呼气容积（FEV1）、FEV1占预计值百分比（FEV1%）及呼气峰值流速（PEF）均明显升高（P<0.05），且观察组FEV1、FEV1%及PEF高于对照组（P<0.05）；治疗后，2组血清TGF-β1、MCP-1及SDF-1水平明显降低（P<0.05），且观察组血清TGF-β1、MCP-1及SDF-1水平低于对照组（P<0.05）。结论 西替利嗪联合BUN治疗哮喘患儿可有效降低血清TGF-β1、MCP-1及SDF-1表达水平，减轻呼吸道炎症反应，从而改善患儿症状，提高治疗效果。 |
| 关键词: 小儿支气管哮喘 西替利嗪 布地奈德 转化生长因子β1 单核细胞趋化蛋白-1 基质细胞衍生因子-1 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.16.014 |
| 分类号:R969.4 |
| 基金项目: |
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| Efficacy of Cetirizine Combined with Budesonide on Children with Bronchial Asthma and its Effects on Levels of Serum TGF-β1, MCP-1 and SDF-1 |
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LI Xinhua, YAN Yijiao, LIN Chunyan, WEI Shengsen
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Yutai People's Hospital, Jining 272300, China
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| Abstract: |
| OBJECTIVE To study the effects of cetirizine combined with budesonide(BUN) on treatment and levels of serum transforming growth factor-β1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and stromal-derived factor-1(SDF-1) in children with bronchial asthma. METHODS Ninety four cases of children with acute episode of asthma were randomly and evenly divided into observation group(cetirizine combined with BUN, n=47) and control group(BUN, n=47), and they were treated for 7 d. The treatment effects, clinical symptoms, pulmonary function indexes and levels of serum TGF-β1, MCP-1 and SDF-1 were compared between the two groups. RESULTS The effective rate of treatment in observation group and control group were 95.74% and 82.98% respectively(P<0.05). The disappearance times of signs of cough, asthmatic symptoms, wheezing and wet rales in observation group were less than those in control group(P<0.05). After treatment, the forced expiratory volume in 1 second(FEV1), the percentage of FEV1 in predicted value(FEV1%) and peak expiratory flow(PEF) were significantly increased in the two groups(P<0.05), and the levels of FEV1, FEV1% and PEF in observation group were higher than those in control group(P<0.05). After treatment, the levels of serum TGF-β1, MCP-1 and SDF-1 were significantly decreased in the two groups(P<0.05), and the levels in observation group were lower than those in control group(P<0.05). CONCLUSION Cetirizine combined with BUN for asthmatic children can effectively reduce the expression levels of serum TGF-β1, MCP-1 and SDF-1, and relieve the respiratory tract inflammation, thereby improving the symptoms and treatment effects. |
| Key words: bronchial asthma in children cetirizine budesonide transforming growth factor-β1 monocyte chemoattractant protein-1 stromal-derived factor-1 |
