| 引用本文: | 曹丽,刘晓妍,石岩硕,庞国勋.大株红景天注射液在PIVAS集中配置后合理使用时间的研究[J].中国现代应用药学,2020,37(19):2366-2370. |
| CAO Li,LIU Xiaoyan,SHI Yanshuo,PANG Guoxun.Study on the Reasonable Using Time of Sofren Injection After Drug Allocation in PIVAS[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(19):2366-2370. |
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| 摘要: |
| 目的 研究大株红景天注射液与5%葡萄糖注射液和0.9%氯化钠注射液2种溶媒在静脉用药集中调配中心（pharmacy intravenous admixture services，PIVAS）集中配置后的合理使用时间。方法 将大株红景天注射液与5%葡萄糖注射液和0.9%氯化钠注射液在PIVAS集中配置后，观测其在常温下0~6 h内外观、pH值、不溶性微粒的变化。利用高效液相色谱法测定其主要成分红景天苷、酪醇在0~6 h内的稳定性。结果 大株红景天注射液与5%葡萄糖注射液和0.9%氯化钠注射配伍后，在常温下0~6 h内其外观、pH值、不溶性微粒均符合中国药典2015年版的要求。其主要成分红景天苷和酪醇的含量在0~6 h内稳定。结论 大株红景天注射液与5%葡萄糖注射液和0.9%氯化钠注射液2种溶媒在PIVAS集中配置后的合理使用时间为6 h。 |
| 关键词: 大株红景天注射液 静脉用药集中调配中心 合理使用时间 高效液相色谱法 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.19.012 |
| 分类号:R917 |
| 基金项目: |
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| Study on the Reasonable Using Time of Sofren Injection After Drug Allocation in PIVAS |
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CAO Li, LIU Xiaoyan, SHI Yanshuo, PANG Guoxun
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Deptarment of Pharmacy, Hebei General Hospital, Shijiazhuang 050000, China
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| Abstract: |
| OBJECTIVE To investigate the reasonable using time of Sofren injection with 5% glucose injection and 0.9% sodium chloride injection after drug allocation in pharmacy intravenous admixture services(PIVAS). METHODS Sofren injection was allocated with 5% glucose injection and 0.9% sodium chloride in PIVAS, and the changes were evaluated in appearance, pH values and insoluble particle in 6 h at room temperature. The stability of salidroside and tyrosol which were the main components of Sofren injection in 6 h was determined by HPLC. RESULTS After the allocation of Sofren injection with 5% glucose injection and 0.9% sodium chloride injection, its appearance, pH values and insoluble particles met the requirements of the Chinese Pharmacopoeia 2015 Edition within 6 h at room temperature. Salidroside and tyrosol were stable within 6 h. CONCLUSION The reasonable using time of Sofren injection with 5% glucose injection and 0.9% sodium chloride injection after drug allocation in PIVAS is 6 h. |
| Key words: Sofren injection PIVAS the reasonable using time HPLC |
