聚多巴胺纳米给药系统用于肿瘤治疗的研究进展

陈美璇; 徐晓玲; 于莲<sup>*</sup>; 杜永忠

引用本文:	陈美璇,徐晓玲,于莲,杜永忠.聚多巴胺纳米给药系统用于肿瘤治疗的研究进展[J].中国现代应用药学,2020,37(6):755-759.
	CHEN Meixuan,XU Xiaoling,YU Lian,DU Yongzhong.Research Progress of Polydopamine Nanoparticles Drug Delivery System for Cancer Treatment[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(6):755-759.

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聚多巴胺纳米给药系统用于肿瘤治疗的研究进展
陈美璇¹, 徐晓玲², 于莲¹, 杜永忠²
1.佳木斯大学药学院, 黑龙江佳木斯 154007;2.浙江大学药学院, 杭州 310058

摘要:

聚多巴胺因具有独特的物理化学性质，如金属离子螯合性、光热转换性、多功能黏性、高化学反应性、高分散性以及良好的生物相容性和可降解性，正受到越来越多的关注。通过对其表面改性并负载相应的功能性物质可实现特定部位的靶向递送，从而高效治疗疾病。本文主要从聚多巴胺的物理化学性质，基于聚多巴胺的药物递送载体在肿瘤治疗领域中的应用及其发展前景3方面出发，对聚多巴胺在药物递送载体中的最新研究进展进行综述。

关键词: 聚多巴胺纳米材料肿瘤治疗递送载体

DOI：10.13748/j.cnki.issn1007-7693.2020.06.025

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基金项目:

Research Progress of Polydopamine Nanoparticles Drug Delivery System for Cancer Treatment

CHEN Meixuan¹, XU Xiaoling², YU Lian¹, DU Yongzhong²

1.School of Pharmacy, Jiamusi University, Jiamusi 154007, China;2.School of Pharmacy, Zhejiang University, Hangzhou 310058, China

Abstract:

Polydopamine has attracted increasing attention due to its unique physical and chemical properties, such as metal ion chelating ability photothermal conversion, multifunctional viscosity, high chemical reactivity, high dispersity, good biocompatibility and biodegradability. Moreover, after surface modification, polydopamine can deliver some functional substances to the specific sites, thereby leading to effective treatments of diseases. The physical and chemical properties of polydopamine-based materials are introduced, and then their applications in cancer treatment are described in detail. Finally, the development prospect of poydopamine-based materials is summarized in this paper, and recent advances in drug delivery vectors based on polydopamine are reviewed.

Key words: polydopamine nanomaterials cancer therapy delivery carrier