| 引用本文: | 郑明,金情政,王也,宋剑锋,胡卫南,徐礼萍.ICP-MS测定衢枳壳中26种无机元素[J].中国现代应用药学,2020,37(12):1493-1497. |
| ZHENG Ming,JIN Qingzheng,WANG Ye,SONG Jianfeng,HU Weinan,XU Liping.Determination of 26 Kinds of Inorganic Elements in Qu Aurantii Fructus by ICP-MS[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(12):1493-1497. |
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| ICP-MS测定衢枳壳中26种无机元素 |
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郑明1, 金情政2, 王也1, 宋剑锋1, 胡卫南1, 徐礼萍1
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1.衢州市食品药品检验研究院, 浙江 衢州 324000;2.浙江衢化医院, 浙江 衢州 324004
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| 摘要: |
| 目的 建立微波消解-电感耦合等离子体质谱（ICP-MS）测定衢枳壳中26种无机元素（Mg、K、Ca、Na、Al、V、Cr、Mn、Fe、Co、Ni、Cu、Zn、Ga、As、Se、Rb、Sr、Ag、Cd、Cs、Ba、Tl、Pb、U、Hg）的方法。方法 样品经微波消解后，采用ICP-MS测定26种无机元素，并进行方法学验证。结果 检测的26种元素线性关系良好（r ≥ 0.999 0），平均回收率为90%~111%，RSD均<5%，精密度、重复性和稳定性试验的RSD均符合定量分析要求，检出限为0.000 7~7.226 4 μg·L-1，测定的6批样品中Mg、K、Ca、Na、Al、Mn、Fe、Cu、Zn、Rb、Sr、Ba含量较高，V、Cr、Co、Ni、Ga、As、Cd、Cs、Tl、Pb、Hg、Se、Ag、U含量较低或未检出。结论 该方法准确、快速、灵敏，适用于衢枳壳中多种无机元素的同时测定。 |
| 关键词: 衢枳壳 电感耦合等离子体质谱法 微波消解 无机元素 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.12.017 |
| 分类号:R917.101 |
| 基金项目:国家药品监督管理局中成药质量评价重点实验室（GZYZZ2020001）；衢州市科技计划指导性项目（2018024） |
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| Determination of 26 Kinds of Inorganic Elements in Qu Aurantii Fructus by ICP-MS |
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ZHENG Ming1, JIN Qingzheng2, WANG Ye1, SONG Jianfeng1, HU Weinan1, XU Liping1
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1.Quzhou Institute for Food and Drug Control, Quzhou 324000, China;2.Zhejiang Quhua Hospital, Quzhou 324004, China
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| Abstract: |
| OBJECTIVE To establish an ICP-MS method for the determination of the amounts of inorganic elements(Mg, K, Ca, Na, Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, As, Se, Rb, Sr, Ag, Cd, Cs, Ba, Tl, Pb, U, Hg) in Qu Aurantii Fructus. METHODS After the microwave digestion, 26 kinds of inorganic elements in the samples were determined by ICP-MS, and the methodology was investigated. RESULTS The 26 kinds of inorganic elements showed the good linearity in the selected concentration ranges (r ≥ 0.999 0), with the average recovery were 90%-111%, while their RSDs were< 5%. The RSD of the precision, repeatability and stability all met the demands of quantitative analysis. The detection limits were in the range of 0.000 7-7.226 4 μg·L-1. The contents of Mg, K, Ca, Na, Al, Mn, Fe, Cu, Zn, Rb, Sr, Ba were higher in the six batchs of samples, and V, Cr, Co, Ni, Ga, As, Cd, Cs, Tl, Pb, Hg, Se, Ag, U were lower or not detected. CONCLUSION This method is accurate, rapid and sensitive, and can satisfy the simultaneous determination of elements in Qu Aurantii Fructus. |
| Key words: Qu Aurantii Fructus ICP-MS microwave digestion inorganic elements |
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