| 引用本文: | 赵啸虎,郭美玲,张红梅.ICP-MS同时测定化风丹中5种常见金属元素的含量[J].中国现代应用药学,2019,36(23):2953-2956. |
| ZHAO Xiaohu,GUO Meiling,ZHANG Hongmei.Simultaneous Determination of the Content of Five Common Metal Elements in Huafeng Dan by ICP-MS[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(23):2953-2956. |
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| 摘要: |
| 目的 建立同时测定化风丹中铜（63Cu）、砷（75As）、镉（114Cd）、汞（202Hg）和铅（208Pb）5种常见金属元素含量的方法。方法 样品用浓硝酸-双氧水（5：1）微波消解后采用微波消解-电感耦合等离子体质谱（ICP-MS）测定5种金属元素的含量，以锗（72Ge）、铟（115In）、铋（209Bi）混合溶液作为内标。结果 该方法对5种金属元素的标准曲线相关系数r>0.999 2，检出限在0.001~0.055 ng·mL-1，加样回收率在85.67%~114.14%，RSD在1.12%~4.26%。结论 该方法专属性强、快速灵敏，适用于化风丹中5种常见金属元素含量的测定。 |
| 关键词: 微波消解 电感耦合等离子体质谱 化风丹 金属元素 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.23.014 |
| 分类号:R917.101 |
| 基金项目: |
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| Simultaneous Determination of the Content of Five Common Metal Elements in Huafeng Dan by ICP-MS |
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ZHAO Xiaohu1, GUO Meiling1, ZHANG Hongmei2
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1.Jilin Institute for Drug Control, Changchun 130033, China;2.Department of Pharmacy, the First Hospital of Jilin University, Changchun 130031, China
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| Abstract: |
| OBJECTIVE To establish a method for simultaneous determination of the content of 5 metal elements(63Cu, 75As, 114Cd, 202Hg, 208Pb) in Huafeng Dan. METHODS The samples were digested with concentrated nitric acid-hydrogen peroxide(5:1), and then microwave digestion-inductively coupled plasma mass spectrometry(ICP-MS) was used to determine the mass concentration of 5 metal elements. 72Ge, 115In, 209Bi were used as internal standards. RESULTS The correlation coefficient of the standard curves of 5 elements was >0.999 2, detection limits were in the range of 0.001-0.055 ng·mL-1, recoveries were in the range of 85.67%-114.14% and RSDs were in the range of 1.12%-4.26%. CONCLUSION The method is specific, accurate and sensitive, and suitable for the content determination of 5 common metal elements in Huafeng Dan. |
| Key words: microwave digestion ICP-MS Huafeng Dan metal elements |
