| 引用本文: | 王单单,郭丽娜,田会东,裴媛,王瑞.基于网络药理学的黄芪治疗心力衰竭作用机制研究[J].中国现代应用药学,2020,37(1):19-24. |
| WANG Dandan,GUO Lina,TIAN Huidong,PEI Yuan,WANG Rui.Study on the Mechanism of Astragalus Membranaceus in the Treatment of Heart Failure Based on Network Pharmacology[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(1):19-24. |
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| 摘要: |
| 目的 利用网络药理学方法探讨黄芪治疗心力衰竭的作用机制。方法 利用TCMSP平台提取出黄芪的化学成分，并通过该数据库检索与活性成分相关的作用靶点；利用CTD在线分析平台查询与心力衰竭相关的靶点。从而构建出成分-靶点、靶点蛋白互作、成分-靶点-生物学通路网络图。结果 通过筛选，得到87个候选化合物，相应靶点326个，其中与心力衰竭相关的靶点36个，这些靶点涉及信号通路27条。结论 本研究对黄芪治疗心力衰竭药效作用机制进行初步探讨，为进一步深入研究提供参考。 |
| 关键词: 网络药理学 黄芪 心力衰竭 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.01.004 |
| 分类号:R966 |
| 基金项目: |
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| Study on the Mechanism of Astragalus Membranaceus in the Treatment of Heart Failure Based on Network Pharmacology |
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WANG Dandan, GUO Lina, TIAN Huidong, PEI Yuan, WANG Rui
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Department of Clinical Pharmacology, Luohe Central Hospital, Luohe 462300, China
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| Abstract: |
| OBJECTIVE To investigate the pharmacology mechanism of Astragalus membranaceus for heart failure based on network pharmacology. METHODS All of chemical components related to the Astragalus membranaceus were collected from the TCMSP database. The targets related to molecular compounds were found through the TCMSP, the targets related to heart failure were found through CTD online analysis platform. Thus, a component-target, target-protein interaction, and component-target-biological pathway network diagram was constructed. RESULTS Eighty seven candidate active molecules, 326 corresponding targets were obtained through network pharmacology screening, 36 targets related to heart failure. These targets could joint in 27 pathways. CONCLUSION The results preliminarily verify the activity components Astragalus membranaceus, and provides a good foundation for further study on the mechanism of action. |
| Key words: network pharmacology Astragalus membranaceus heart failure |
