| 引用本文: | 王华炜,王路乔,孟照辉.心脉隆注射液治疗心血管疾病研究进展[J].中国现代应用药学,2019,36(23):2995-3000. |
| WANG Huawei,WANG Luqiao,MENG Zhaohui.Research Progress of Xinmailong Injection in the Treatment of Cardiovascular Disease[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(23):2995-3000. |
|
| 摘要: |
| 心血管疾病是严重危害人类健康的疾病之一。体内外研究表明，从药用昆虫美洲大蠊中提取的心脉隆注射液含有结合氨基酸和复合核苷碱基等多种成分，对防治心血管疾病具有调脂、抗炎抗氧化、抗动脉粥样硬化、改善内皮功能、降低肺动脉压、增强心肌收缩、抑制心室重构、减轻心肌缺氧缺血及再灌注损伤、抗心律失常、促进干细胞向神经元细胞分化等多种作用机制；临床在治疗心力衰竭、慢性肺源性心脏病、脓毒症心肌损伤、心肾综合征、冠心病心绞痛及急性心肌梗死心源性休克等方面都有相应研究。本文就以上方面对心脉隆注射液防治心血管疾病进行综述。 |
| 关键词: 心血管疾病 心脉隆注射液 研究进展 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.23.023 |
| 分类号:R969 |
| 基金项目:国家自然科学基金项目（81860073，81860074）；昆明医科大学2018年博士创新基金项目（2018D001） |
|
| Research Progress of Xinmailong Injection in the Treatment of Cardiovascular Disease |
|
WANG Huawei, WANG Luqiao, MENG Zhaohui
|
|
Laboratory of Molecular Cardiology, Yunnan Institute of Cardiovascular Diseases, Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
|
| Abstract: |
| Cardiovascular disease is one of the diseases that seriously endanger human health. In vitro and in vivo studies have shown that Xinmailong injection extracted from the medicinal insect American cockroach contains a combination of amino acids and complex nucleobases, which could regulate lipids, anti-inflammatory and anti-oxidative, anti-atherosclerosis, improve endothelial function, reduce pulmonary artery pressure and enhance myocardial contraction, inhibit ventricular remodeling, reduce myocardial hypoxia-ischemia and reperfuse injury, anti-arrhythmia, promote differentiation of stem cells into neuronal cells, etc. In the treatment of heart failure, chronic pulmonary heart disease, sepsis myocardial injury, heart and kidney syndrome, coronary heart disease angina pectoris and acute myocardial infarction cardiogenic shock and other aspects have been studied. This article reviewed the above aspects of the prevention and treatment of cardiovascular disease by Xinmailong injection. |
| Key words: cardiovascular disease Xinmailong injection research progress |
