| 引用本文: | 李煜,王丹.粉末X-射线衍射技术定量测定氨糖美辛肠溶片中吲哚美辛晶型γ的含量[J].中国现代应用药学,2019,36(21):2683-2686. |
| LI Yu,WANG Dan.Quantitative Analysis of Indomethacin Crystal Type γ Content in Glucosamine and Indomethacin Enteric-coated Tablets by Powder X-ray Diffraction[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(21):2683-2686. |
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| 摘要: |
| 目的 采用粉末X-射线衍射技术（powder X-ray diffraction，PXRD）对氨糖美辛肠溶片中吲哚美辛晶型γ的含量进行定量分析。方法 采用精细扫描方法，扫描范围9~12°，扫描速度5秒/步，步长0.02°。结果 氨糖美辛肠溶片中吲哚美辛晶型γ含量线性方程为y=13 728x+1 131（r=0.990 8），检测限为21.2 mg·g-1（S/N=4.6）。胶囊剂中晶型γ含量为45.73%~50.40%。结论 本法操作简单，在辅料没有干扰的情况下可用于氨糖美辛肠溶片中吲哚美辛晶型γ含量的定量分析和快速检测。 |
| 关键词: 吲哚美辛 粉末X-射线衍射 定量测定 晶型含量 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.21.010 |
| 分类号:R917.101 |
| 基金项目:浙江省食品药品监管系统科技计划项目（2018015） |
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| Quantitative Analysis of Indomethacin Crystal Type γ Content in Glucosamine and Indomethacin Enteric-coated Tablets by Powder X-ray Diffraction |
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LI Yu, WANG Dan
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Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China
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| Abstract: |
| OBJECTIVE To establish a quantitative analysis of indomethacin crystal type γ content in glucosamine and indometacin enteric-coated tablets by powder X-ray diffraction(PXRD). METHODS The fine scanning method was adopted. The scan range was 9-12°, the scan speed was 5 s per step and the step size was 0.02°. RESULTS The linear equation was y=13 728x+1 131(r=0.990 8). The detection limit was 21.2 mg·g-1(S/N=4.6). The content of indomethacin crystal type γ in glucosamine and indometacin enteric-coated capsules was 45.73%-50.40%. CONCLUSION The method was simple in operation, which can be used for quantitative analysis of indomethacin crystal type γ content in glucosamine and indometacin enteric-coated tablets while no interference with excipient. It could be a rapid detection method for control crystal type γ content. |
| Key words: indomethacin powder X-ray diffraction quantitative determination crystal type content |
