| 引用本文: | 巩佳威,曲晓宇,高凤,李楠.依托泊苷、表柔比星与环磷酰胺在输液中的配伍稳定性考察[J].中国现代应用药学,2019,36(20):2584-2587. |
| GONG Jiawei,QU Xiaoyu,GAO Feng,LI Nan.Study on the Compatible Stability of Etoposide for Injection with Epirubicin and Cyclophmide[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(20):2584-2587. |
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| 摘要: |
| 目的 对依托泊苷、表柔比星与环磷酰胺混合配伍稳定性进行考察，为临床用药安全提供依据。方法 分别考察24 h内25℃常温、25℃避光、4℃冷藏避光条件下3种药物的含量、pH及不溶性微粒的稳定性。结果 3种药物混合溶液的含量、pH值与不溶性微粒在24 h内25℃常温、25℃避光、4℃冷藏避光条件下均未发生明显变化。结论 3种药物的配伍溶液在24 h内稳定性良好，可以为临床用药提供依据。 |
| 关键词: 依托泊苷 表柔比星 环磷酰胺 配伍 稳定性 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.20.020 |
| 分类号:R944.4 |
| 基金项目: |
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| Study on the Compatible Stability of Etoposide for Injection with Epirubicin and Cyclophmide |
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GONG Jiawei, QU Xiaoyu, GAO Feng, LI Nan
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The First Hospital of Jilin University, Changchun 130000, China
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| Abstract: |
| OBJECTIVE To investigate the stability of etoposide, epirubicin and cyclophosphamide injection and provide a basis on clinical usage. METHODS Drug contents, pH values and insoluble particles were determined in three storage situation as 25℃, 25℃ in the dark and 4℃ in the dark, respectively for 24 h. RESULTS The contents, pH values and insoluble particles were stable in three situations. CONCLUSION The compatibility of etoposide, epirubicin and cyclophosphamide has good stability during 24 h, which provide a basis for clinical usage. |
| Key words: etoposide epirubicin cyclophmide compatible stability |
