抗真菌药物的系统分类、耐药机制及新药研发进展

韩晓燕; 宋亚丽; 白埔; 牛艺璇; 赵娜; 苏长海; 苏伊新; 肖斌<sup>*</sup>

引用本文:	韩晓燕,宋亚丽,白埔,牛艺璇,赵娜,苏长海,苏伊新,肖斌.抗真菌药物的系统分类、耐药机制及新药研发进展[J].中国现代应用药学,2019,36(11):1430-1436.
	HAN Xiaoyan,SONG Yali,BAI Pu,NIU Yixuan,ZHAO Na,SU Changhai,SU Yixin,XIAO Bin.Systematic Classification of Antifungal Drugs, Resistance Mechanisms and Development of New Drugs[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(11):1430-1436.

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抗真菌药物的系统分类、耐药机制及新药研发进展
韩晓燕¹, 宋亚丽², 白埔¹, 牛艺璇¹, 赵娜¹, 苏长海¹, 苏伊新¹, 肖斌¹
1.内蒙古医科大学鄂尔多斯临床医学院, 临床药学实验室, 内蒙古鄂尔多斯 017000;2.河北大学药学院, 河北省药品质量控制重点实验室, 河北保定 071002

摘要:

由于癌症放化疗、器官移植等患者人数的增加以及广谱抗菌药物的广泛使用，白念珠菌、新型隐球菌等深部真菌感染病例急剧增加，严重威胁人类健康。目前治疗真菌感染的药物按作用靶点可分为7类，但是耐药性严重、抗菌谱窄、不良反应多等问题限制了其临床应用，开发安全、有效的抗真菌新药成为一个亟待解决的难题。本文从抗真菌药物的分类、耐药机制和新药的研发3个方面进行综述，以期为抗真菌药物的进一步研发提供参考。

关键词: 抗真菌耐药机制作用机制研究进展

DOI：10.13748/j.cnki.issn1007-7693.2019.11.025

分类号:R978.5

基金项目:内蒙古自然科学基金面上项目（2017MS0870）；内蒙古自治区"草原英才"工程青年创新人才项目（内人社办发[2016]348号）；内蒙古医科大学科技百万工程联合项目[YKD2017KJBW（LH）023]

Systematic Classification of Antifungal Drugs, Resistance Mechanisms and Development of New Drugs

HAN Xiaoyan¹, SONG Yali², BAI Pu¹, NIU Yixuan¹, ZHAO Na¹, SU Changhai¹, SU Yixin¹, XIAO Bin¹

1.Ordos School of Clinical Medicine, Laboratory of Clinical Pharmacy, Inner Mongolia Medical University, Ordos 017000, China;2.College of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China

Abstract:

With cancer chemotherapy, radiation therapy, and organ transplants generally carried out, and broad-spectrum antibiotics widely used in clinic, incidence of Candida albicans, Cryptococcus neoformans and other invasive fungal infections incidence has been rising sharply, which is a serious threaten to human health. At present, antifungal agents can be divided into seven categories according to their action targets. Nevertheless, the clinical application of antifungal agents were limited for their serious resistance, narrow antifungal spectrum and adverse effects. Thus, the development of new safe and effective antifungal agents has become a difficult problem to be solved. This paper reviewed the classification, resistance mechanisms, and the new development of antifungal agents, in order to provide reference for the future research direction.

Key words: antifungal resistance mechanism mechanism of action research progress