| 引用本文: | 赵德华,王继生,楚明明,龚晶淼,孙丽琼,罗文,曹莉莎,刘真宏,陈静.抗肿瘤药物引起手足综合征的机制及防治措施[J].中国现代应用药学,2019,36(11):1437-1442. |
| ZHAO Dehua,WANG Jisheng,CHU Mingming,GONG Jingmiao,SUN Liqiong,LUO Wen,CAO Lisha,LIU Zhenhong,CHEN Jing.Mechanisms and Preventive Measures of Hand-foot Syndrome Induced by Antineoplastic Drugs[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(11):1437-1442. |
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| 抗肿瘤药物引起手足综合征的机制及防治措施 |
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赵德华1, 王继生1, 楚明明2, 龚晶淼1, 孙丽琼1, 罗文1, 曹莉莎1, 刘真宏1, 陈静1
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1.绵阳市第三人民医院四川省精神卫生中心临床药学科, 四川 绵阳 621000;2.陆军军医大学第二附属医院临床药学科, 重庆 400037
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| 摘要: |
| 多种抗肿瘤药物均可导致手足综合征的发生，通常表现为手掌和脚掌的皮肤出现感觉异常、红斑、红肿、疼痛、水泡、脱皮、脱屑、溃疡等。症状轻者可导致药物减量，严重者可致停药，降低患者依从性，影响药物疗效。本文通过检索相关文献，对手足综合征的发生机制和防治措施进行梳理和归纳，以期为临床用药提供参考依据。 |
| 关键词: 抗肿瘤药物 手足综合征 依从性 机制 防治措施 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.11.026 |
| 分类号:R969 |
| 基金项目:成都药学会正大天晴科研基金（201718） |
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| Mechanisms and Preventive Measures of Hand-foot Syndrome Induced by Antineoplastic Drugs |
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ZHAO Dehua1, WANG Jisheng1, CHU Mingming2, GONG Jingmiao1, SUN Liqiong1, LUO Wen1, CAO Lisha1, LIU Zhenhong1, CHEN Jing1
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1.Department of Clinical Pharmacy, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang 621000, China;2.Department of Clinical Pharmacy, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, China
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| Abstract: |
| A variety of antineoplastic agents can lead to hand-foot syndrome(HFS), which usually characterized by abnormal skin sensation, erythema, inflamed, pain, blisters, desquamation, desquamation, ulcers and so on. Mild symptoms can lead to drug reduction, while severe symptoms can directly lead to discontinuation of drugs, so that can reduce the compliance of patients and affecting the efficacy of drugs. By retrieving relevant literature, the mechanism and management of HFS are sorted and summarized in this paper, so as to provide reference for clinical drug use. |
| Key words: antineoplastic agents hand-foot syndrome compliance mechanism preventive measures |
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