| 引用本文: | 陈圻,黄文海,沈正荣,马臻.上皮-间质转化在肺纤维化中的研究进展[J].中国现代应用药学,2019,36(9):1155-1160. |
| CHEN Qi,HUANG Wenhai,SHEN Zhengrong,MA Zhen.Research Progress of Epithelial-mesenchymal Transition in Pulmonary Fibrosis[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(9):1155-1160. |
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| 摘要: |
| 肺纤维化是众多肺部疾病的最终表现结果，其形成过程十分复杂，发生的机制也尚未完全阐明。目前的研究发现，上皮-间质转化（epithelial-mesenchymal transition，EMT）是肺纤维化发病机制中的一个关键步骤。转化生长因子-β、Notch和Wingless-type信号通路是普遍认可的介导调控EMT的信号通路。微小核糖核酸及内质网应激等在EMT过程中发挥重要作用。充分认识EMT在肺纤维化发生发展中的作用，有助于寻找治疗肺纤维化的新方法和新药物。本文就近年来国内外学者对EMT在肺纤维化中的研究新进展进行综述。 |
| 关键词: 肺纤维化 上皮-间质转化 发病机制 转化生长因子-β 微小核糖核酸 内质网应激 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.09.027 |
| 分类号:R966 |
| 基金项目:浙江省科技计划项目（2017F30004）；浙江省神经精神疾病药物研究重点实验室（2019E10021）；浙江省医学重点学科群项目（XKQ-010-001）；浙江省自然科学基金（LY16H310010） |
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| Research Progress of Epithelial-mesenchymal Transition in Pulmonary Fibrosis |
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CHEN Qi, HUANG Wenhai, SHEN Zhengrong, MA Zhen
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Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China
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| Abstract: |
| Pulmonary fibrosis is the final manifestation of many lung diseases. The formation of lung fibrosis is complex and the mechanism of its occurrence has not been clearly elucidated yet. Recent research showed that epithelial-mesenchymal transition(EMT) is a key step of pulmonary fibrosis. Major signaling pathways involve in EMT include transforming growth factor-β, Notch and Wingless-type signaling pathways. MicroRNAs and endoplasmic reticulum stress play critical roles in the process of EMT. Fully understanding the role of EMT in the development of pulmonary fibrosis will be conducive in search of new methods and new drugs for the treatment of pulmonary fibrosis. In this paper, the latest impacts of EMT on pulmonary fibrosis were systematically reviewed. |
| Key words: pulmonary fibrosis epithelial-mesenchymal transition pathogenesis transforming growth factor-β microRNAs endoplasmic reticulum stress |
