醇传递体在透皮给药系统中的研究进展

赵丹丹; 于莲; 冯幸福; 戚映丹; 应晓英<sup>*</sup>; 高建青<sup>*</sup>

引用本文:	赵丹丹,于莲,冯幸福,戚映丹,应晓英,高建青.醇传递体在透皮给药系统中的研究进展[J].中国现代应用药学,2019,36(9):1166-1171.
	ZHAO Dandan,YU Lian,FENG Xingfu,QI Yingdan,YING Xiaoying,GAO Jianqing.Advances in Research of Transethosome in Transdermal Drug Delivery System[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(9):1166-1171.

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醇传递体在透皮给药系统中的研究进展
赵丹丹^1,2, 于莲¹, 冯幸福³, 戚映丹³, 应晓英², 高建青²
1.佳木斯大学药学院, 黑龙江佳木斯 154007;2.浙江大学药学院, 杭州 310058;3.宁波赛缪斯生物科技有限公司, 浙江宁波 315806

摘要:

由于角质层的限速屏障作用，大部分药物透过皮肤的能力较差。醇传递体因能够将药物传递到皮肤深层和全身循环，且制备方法简单，使用安全而受到关注，为药物的经皮渗透提供了新的传递载体。醇传递体具有高度变形性、促进药物经皮渗透、缓释、防止药物代谢降解等优点，在药物的经皮吸收方面具有广阔的应用价值和开发前景。本文通过查阅国内外文献对醇传递体在透皮给药系统中的研究和应用等方面进行综述，为其今后在透皮领域的进一步发展提供借鉴。

关键词: 醇传递体透皮给药系统制备方法研究进展

DOI：10.13748/j.cnki.issn1007-7693.2019.09.029

分类号:

基金项目:

Advances in Research of Transethosome in Transdermal Drug Delivery System

ZHAO Dandan^1,2, YU Lian¹, FENG Xingfu³, QI Yingdan³, YING Xiaoying², GAO Jianqing²

1.College of Pharmaceutical Sciences, Jiamusi University, Jiamusi 154007, China;2.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China;3.Ningbo Saimuse Biotechnology Co., Ltd., Ningbo 315806, China

Abstract:

The rate limiting barrier of the stratum corneum influences the transdermal performance in most drugs. Strong points such as deep-layer skin and systemic circulation delivery, accessible fabrication and safety in use make transethosome welcomed worldwide. It is a new delivery carrier that transethosome acts as for percutaneous penetration. Because of the high deformability, promotion in drug percutaneous penetration, sustained release and drug degradation prevention, transethosome owns a wide application future and development prospect in the field of drug percutaneous absorption. To provide references for the future development in terms of transdermal drug delivery system, a brief review is summarized through revising domestic and foreign literatures.

Key words: transethosome transdermal drug delivery system the method of preparation research progress