| 引用本文: | 彭德乾,饶州,白丽丽,陈训,张军锋,王灿红.三桠苦枝叶化学成分的分离、鉴定[J].中国现代应用药学,2019,36(4):430-432. |
| PENG Deqian,RAO Zhou,BAI Lili,CHEN Xun,ZHANG Junfeng,WANG Canhong.Isolation and Identification of Chemical Constituents from Twigs and Leaves of Evodia lepta (Spreng.) Merr[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(4):430-432. |
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| 三桠苦枝叶化学成分的分离、鉴定 |
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彭德乾1, 饶州2, 白丽丽1, 陈训1, 张军锋2, 王灿红3
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1.海南医学院药学院, 海口 571199;2.海南大学材料与化工学院, 热带生物资源教育部重点实验室, 海口 570228;3.中国医学科学院药用植物研究所海南分所, 海口 570311
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| 摘要: |
| 目的 研究三桠苦[Evodia lepta（Spreng.）Merr.]枝叶的化学成分，为三桠苦的进一步研究奠定物质基础。方法 对三桠苦无水乙醇提取物的乙酸乙酯萃取物采用硅胶柱层析分离纯化，得到单体化合物，经波谱分析鉴定其化合物结构。结果 从三桠苦乙酸乙酯萃取物中分离得到6个单体化合物，分别为异吴茱萸酮酚（化合物1）、异吴茱萸酮酚甲醚（化合物2）、3，5-二羟基-4-乙氧基-6-乙酰基-7-甲氧基-2，2-二甲基苯并二氢吡喃（化合物3）、（cis）-3，4，5-三羟基-6-乙酰基-7-甲氧基-2，2-二甲基色烷（化合物4）和（trans）-3，4-二羟基-5-甲氧基-6-乙酰基-7-甲氧基-2，2-二甲基色烷（化合物5）和对羟基苯甲酸丁酯（化合物6）。结论 化合物1~6均为首次从三桠苦植物的枝叶中分离得到。 |
| 关键词: 三桠苦 异吴茱萸酮酚 色烷 甲醚 呋喃 酯 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.04.010 |
| 分类号:R284.1 |
| 基金项目:国家自然科学基金项目（31360210）；海南省科协青年科技英才学术创新计划项目（QCXM201707）；海南医学院引进人才科研启动基金 |
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| Isolation and Identification of Chemical Constituents from Twigs and Leaves of Evodia lepta (Spreng.) Merr |
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PENG Deqian1, RAO Zhou2, BAI Lili1, CHEN Xun1, ZHANG Junfeng2, WANG Canhong3
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1.School of Pharmacy, Hainan Medical College, Haikou 571199, China;2.Materials and Chemical Engineering Institute, Hainan University, Key Laboratory of Tropical Biological Resources of Ministry of Education, Haikou 570228, China;3.Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou Hainan 570311, China
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| Abstract: |
| OBJECTIVE To study the chemical constituents from the twigs and leaves of Evodia lepta (Spreng.) Merr.. In order to lay a substantial foundation for the further research. METHODS The ethyl acetate fraction of anhydrous ethanol extract from Evodia lepta (Spreng.) Merr. was separated and purified by silica gel column chromatography. The structures of the compounds were identified by nuclear magnetic resonance (NMR) spectrometry. RESULTS Six compounds were isolated as isoevodionol (compound 1), isoevodionol methyl ether(compound 2), 3,5-dihydroxy-4-ethoxy-6-acetyl-7-methoxy-2,2-dimethylchroman (compound 3),(cis)-3,4,5-trihydroxy-6-acetyl-7-methoxy-2,2-dimethylchroman(compound 4), (trans)-3,4-dihydroxy-5-methoxy-6-acetyl-7-methoxy-2,2-dimethylchroman (compound 5), butylparaben (compound 6). CONCLUSION The compounds(compound 1-6) are isolated from the twigs and leaves of Evodia lepta (Spreng.) Merr. for the first time. |
| Key words: Evodia lepta (Spreng.) Merr. isoevodionol chroman methyl ether furan ester |
