| 引用本文: | 蒲梦如,刘建辉.Nrf2信号通路与胰腺β细胞功能障碍[J].中国现代应用药学,2019,36(8):1001-1006. |
| PU Mengru,LIU Jianhui.Relationship of Nrf2 Signaling Pathway to the Dysfunction of Pancreatic β Cells[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(8):1001-1006. |
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| 摘要: |
| 核转录因子E2相关因子2（nuclear factor elytroid-derived factor 2-related factor，Nrf2）是维持细胞氧化还原稳态的中枢调节者，激活Nrf2在细胞水平和动物模型中均能拮抗氧化应激，表现出抗氧化、抗凋亡作用。近年来，大量的实验研究表明，氧化应激与2型糖尿病的形成和发展有着密切关系，而Nrf2信号通路在调节胰腺β细胞功能障碍和胰岛素分泌过程中具有重要作用。本文围绕Nrf2在胰腺β细胞功能障碍中的作用及其机制展开综述，以进一步了解Nrf2在2型糖尿病形成、发展及防治中的作用。 |
| 关键词: 核转录因子E2相关因子2 氧化应激 功能障碍 2型糖尿病 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.08.021 |
| 分类号:R966 |
| 基金项目:国家自然科学基（81373459）；重庆市科委重点项目（CSTC，2015jcyjbx0064）；重庆市科技创新领军人才（2014kjcxljrc0018）；重庆市优秀科技创新团队（CXTDX201601031）；重庆理工大学研究生创新项目资助（ycx2018249） |
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| Relationship of Nrf2 Signaling Pathway to the Dysfunction of Pancreatic β Cells |
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PU Mengru, LIU Jianhui
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Chongqing Key Lab of Medicinal Chemistry & Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China
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| Abstract: |
| An impressive number of references suggest that nuclear factor elytroid-derived factor 2-related factor (Nrf2) is the key player keeping the balance of redox state in vitro and in vitro. Activation of Nrf2 induces the expression of several genes, which are associated with anti-oxidation and anti-apoptosis. The increasing data demonstrates that oxidative stress is associated with the development of type 2 diabetes mellitus, and Nrf2 signaling pathway is involved in the improvement of dysfunction of pancreatic beta cells and glucose-stimulated insulin secretion. Here, we try to summary the current advances about the role and its relative mechanisms of Nrf2 on the dysfunction of pancreatic beta cells, which might be beneficial and helpful to prevention of type 2 diabetes mellitus. |
| Key words: nuclear factor elytroid-derived factor 2-related factor (Nrf2) oxidative stress dysfunction type 2 diabetes mellitus(T2DM) |
