| 引用本文: | 戴媛媛,马明华,汪晓河,张婧婷,计强国,年华.马兜铃酸肾不良反应及质量控制研究进展[J].中国现代应用药学,2019,36(10):1304-1310. |
| DAI Yuanyuan,MA Minghua,WANG Xiaohe,ZHANG Jingting,JI Qiangguo,NIAN Hua.Advances of the Nephrotoxic Effects and Quality Control of Aristolochic Acid[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(10):1304-1310. |
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| 摘要: |
| 马兜铃酸为硝基菲类有机酸类化合物，是马兜铃、关木通、细辛等植物的主要成分。马兜铃酸药理作用广泛，有抗感染、抗肿瘤、增强细胞免疫等功能。本文总结了马兜铃酸肾毒性研究进展及其分子结构，并对近5年不同中药材和中成药中马兜铃酸质量控制的研究进行综述，对比分析不同检测方法的优缺点，为今后对马兜铃酸的进一步研究及临床合理应用提供依据。 |
| 关键词: 马兜铃酸 肾毒性 质量控制 检测方法 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.10.029 |
| 分类号:R282 |
| 基金项目:上海市卫生和计划生育委员会科研项目（201440386）；上海中医药大学高峰高原学科项目（KY111.20.81）；上海市科学技术委员会科研计划项目（16401902100） |
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| Advances of the Nephrotoxic Effects and Quality Control of Aristolochic Acid |
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DAI Yuanyuan1, MA Minghua2, WANG Xiaohe1, ZHANG Jingting1, JI Qiangguo1, NIAN Hua1
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1.Pharmaceutical Center of Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;2.Pharmaceutical Center of Yangpu District Central Hospital, Shanghai 200090, China
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| Abstract: |
| Aristolonic acid is a nitro phenanthrene organic acid compound which is found as a main component of Fructus Aristolochiae, Caulis aristolochiae Manshuriensis, Asari Radix et Rhizoma and many other medicinal plants. Aristolochic acid has extensive pharmaceutical action, it has function such as anti infection, anti tumor, abortifacient and cellular immunity enhancing properties. This article summarize the research progress of nephrotoxicity and the molecular structure of aristolochic acid and also give a rewiew on the quality control research of aristolochic acid in different Chinese herbal medicines and Chinese patent medicines in recent five years. This paper compared and analyzed the advantages and disadvantages of different detection methods, which may provide the basis for the further research and clinical application of aristolochic acid in the future. |
| Key words: aristolochic acid nephrotoxic quality control detection methods |
