| 引用本文: | 李坤丽,常新林,胡亚丹,钟婷,张翰霖,张园园.稀有糖L-半乳糖及其衍生物的合成研究[J].中国现代应用药学,2019,36(4):417-420. |
| LI Kunli,CHANG Xinlin,HU Yadan,ZHONG Ting,ZHANG Hanlin,ZHANG Yuanyuan.Study on the Synthesis of Uncommon Sugar of L-galactose and Its Derivatives[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(4):417-420. |
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| 摘要: |
| 目的 制备L-半乳糖及其中间体D-半乳糖醛酸、L-半乳糖酸-1，4-内酯，并优化工艺。方法 采用酶法水解果胶，制备D-半乳糖醛酸，并用正交试验设计法确立最佳酶水解工艺；D-半乳糖醛酸经还原、脱水转化为L-半乳糖酸-1，4-内酯，进一步还原合成L-半乳糖。结果 酶水解最佳条件为50℃反应2 h，酶-果胶比为1.5：10。合成产物结构经1H-NMR、13C-NMR表征。合成产率为31.4%。结论 方法操作简便，步骤短，反应收率高，具有工业化生产前景。 |
| 关键词: L-半乳糖 D-半乳糖醛酸 L-半乳糖酸-1,4-内酯 果胶 合成 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.04.007 |
| 分类号:R914 |
| 基金项目: |
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| Study on the Synthesis of Uncommon Sugar of L-galactose and Its Derivatives |
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LI Kunli, CHANG Xinlin, HU Yadan, ZHONG Ting, ZHANG Hanlin, ZHANG Yuanyuan
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School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China
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| Abstract: |
| OBJECTIVE L-galactose and its intermediate D-galacturonic acid and L-galactonic acid-1,4-lactones were prepared and optimized. METHODS D-galacturonic acid was prepared by enzymatic hydrolysis of pectin, and the best enzymatic hydrolysis technology was established by orthogonal experimental design. L-galactonic acid-1,4-lactones was synthesized from D-galacturonic acid via reduction and dehydration, L-galactose was synthesized from L-galactonic acid-1,4-lactones via reduction. RESULTS The optimum conditions for enzymatic hydrolysis were as follow:hydrolysis temperature was 50℃, The reaction time was 2 h, the enzyme-pectin ratio was 1.5:10. The structure of products were characterized by 1H-NMR and 13C-NMR. The yield was 31.4%. CONCLUSION The method is simple and convenient, with short steps and high yield. It can be applied to industrial production. |
| Key words: L-galactose D-galacturonic acid L-galactonic acid-1,4-lactone pectin synthesis |
