| 引用本文: | 接丽莉,郑雪花,杨跃辉.头孢替唑钠联合炎琥宁注射液治疗感染性心内膜炎的meta分析[J].中国现代应用药学,2019,36(2):215-220. |
| JIE Lili,ZHENG Xuehua,YANG Yuehui.Meta-analysis of Cefazolin Sodium for Azole Combined with Yanhuning Injection in Treatment of Acute Infective Valve Endocarditis[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(2):215-220. |
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| 摘要: |
| 目的 系统评价头孢替唑钠与炎琥宁注射液联合使用治疗急性感染性心内膜炎的有效性和安全性，以期为联合用药的合理性提供循证依据。方法 计算机检索中国知网、万方数据库、维普数据库和中国生物医学文献数据库1990年1月至2018年2月的相关随机对照试验。2位研究者分别进行文献筛选和质量评价，采用Rev Man 5.3软件，对符合标准文献的有效性和安全性进行meta分析。结果 纳入11篇符合标准的文献，meta分析结果显示试验组（头孢替唑钠与炎琥宁注射液联合使用）与对照组（单用头孢替唑钠）的有效率存在统计学差异[OR=4.07，95% CI（2.66，6.25），Z=6.43，P<0.000 01]，试验组的总有效率优于对照组。其中7篇含有不良反应的结局指标，meta分析结果显示试验组与对照组的不良反应发生率无统计学差异[OR=0.60，95% CI（0.29，1.28），Z=1.32，P=0.19]。结论 头孢替唑钠联合炎琥宁注射液治疗急性感染性心内膜炎的有效率优于单独使用头孢替唑钠，但是2组的不良反应发生率无明显差异。 |
| 关键词: 急性感染性心内膜炎 头孢替唑钠 炎琥宁注射液 meta分析 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.02.017 |
| 分类号:R969.3 |
| 基金项目: |
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| Meta-analysis of Cefazolin Sodium for Azole Combined with Yanhuning Injection in Treatment of Acute Infective Valve Endocarditis |
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JIE Lili, ZHENG Xuehua, YANG Yuehui
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Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang 110004, China
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| Abstract: |
| OBJECTIVE To evaluate the effectiveness and safety of cefazolin sodium for azole combined with Yanhuning injection in treatment of the acute infective valve endocarditis, in order to provide basis for evidence-based in the rationality of the combination. METHODS Retrieved from CNKI, Wanfang database, Weipu database, CBM searching RCTs from January 1990 to February 2018. The two evaluators choose trials and evaluated quality, valid data were entered meta-analysis by Rev Man 5.3 software. RESULTS Eleven RCTs were included in effectiveness. From the results of meta-analysis, the effectiveness of test group (cefazolin sodium for azole combined with Yanhuning injection) was superior to the control group(single use of cephalosporins for azole sodium) with statistical significance[OR=4.07, 95%CI(2.66, 6.25), Z=6.43, P<0.000 01]. Seven RCTs were included outcome indicators of adverse reactions. From the results of meta-analysis, test group was same to the control group in the incidence of adverse drug reaction without statistical significance[OR=0.60, 95%CI(0.29, 1.28), Z=1.32, P=0.19]. CONCLUSION The effectiveness of cefazolin sodium for azolein combined with Yanhuning injection in treatment of the acute infective valve endocarditis is superior than the single use of cephalosporins for azole sodium, but there is no difference between the two groups in the incidence of adverse drug reaction. |
| Key words: acute infective valve endocarditis cefazolin sodium for azole Yanhuning injection meta-analysis |
