| 引用本文: | 贾莉,朱亚宏,付英,林嘉欣.复方苦参注射液对培美曲塞联合卡铂方案治疗非小细胞肺癌的有效性与安全性评价[J].中国现代应用药学,2018,35(10):1533-1537. |
| JIA Li,ZHU Yahong,FU Ying,LIN Jiaxing.Evaluation on Efficiency and Safety of Compound Kushen Injection in the Treatment of Non-small Cell Lung Cancer on the Basis of Pemetrexed and Carboplatin[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(10):1533-1537. |
|
| 摘要: |
| 目的 评价复方苦参注射液对培美曲塞联合卡铂方案治疗非小细胞肺癌有效性与安全性的提高作用。方法 纳入2016年1月—2017年9月收治的80例非小细胞肺癌患者作为研究对象，并回顾性分析临床病例资料。根据治疗方式的不同，分为观察组（n=42）与对照组（n=38）。对照组采用培美曲塞+卡铂治疗，观察组采用复方苦参注射液+培美曲塞+卡铂治疗。观察并比较2组患者的治疗效果。结果 治疗后，与对照组比较，观察组患者生活质量明显改善（P<0.05）； CD3+、CD4+、CD4+/CD8+显著升高（P<0.05），而CD8+明显降低（P<0.05）；患者炎性指标（IL-6、IL-10、TNF-α）水平明显较低，近期治疗有效率与疾病控制率均较高（P<0.05），且患者生存期明显延长，不良反应发生率更低（P<0.05）。结论 复方苦参注射液联合培美曲塞卡铂方案治疗非小细胞肺癌，能显著改善患者生活质量，提高其免疫功能，并降低机体炎性水平，治疗安全有效。 |
| 关键词: 复方苦参注射液 培美曲塞 卡铂 治疗效果 生活质量 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.10.022 |
| 分类号:R969.3 |
| 基金项目: |
|
| Evaluation on Efficiency and Safety of Compound Kushen Injection in the Treatment of Non-small Cell Lung Cancer on the Basis of Pemetrexed and Carboplatin |
|
Jiali,zhu ya hong and fuying
|
|
1 Department of respiratory medicine, Yuncheng Central Hospital, Shanxi,Department of Urology, Yuncheng Central Hospital, Shanxi Province,1 Department of respiratory medicine, Yuncheng Central Hospital, Shanxi
|
| Abstract: |
| OBJECTIVE To evaluate the improvement in the efficiency and safety of Compound Kushen injection in the treatment of non-small cell lung cancer on the basis of pemetrexed and carboplatin. METHODS The 80 patients with non-small cell lung cancer were treated from January 2016 to September 2017. They were considered as study objects and the clinical data were analyzed retrospectively. They were divided into observation group (n=42) and control group (n=38). The patients were treated with Compound Kushen injection, pemetrexed and carboplatin in the observation group, while the patients were treated with pemetrexed and carboplatin in the control group. The treatment effects were observed and compared. RESULTS Compared with control group after treatment, in the observation group, the improvement about quality of life was significantly better (P<0.05); the CD3+, CD4+ and CD4+/CD8+ were significantly higher (P<0.05), while the CD8+ was significantly lower (P<0.05); the levels of inflammatory indexes (IL-6, IL-10, TNF-α) were better (P<0.05); the effective rate and disease control rate were significantly higher (P<0.05); besides, the progression free survival and overall survival in the observation group were significantly higher (P<0.05); the adverse reaction of patients was significantly lower (P<0.05). CONCLUSION Compound Kushen injection, pemetrexed and carboplatin used in the treatment process of non-small cell lung cancer can effectively improve quality of life and immune function, reduce the level of inflammation indexes. The therapeutic regimen is safe and effective. |
| Key words: Compound Kushen injection pemetrexed carboplatin treatment effect life quality |
