| 引用本文: | 黄雍,文敏,杨磊,戴冰,李玉星.正交设计优选化瘀散凝胶贴膏基质配方[J].中国现代应用药学,2018,35(9):1299-1302. |
| HUANG Yong,WEN Min,YANG Lei,DAI Bing,LI Yuxing.Study on Optimizing Matrix Formulation of Huayusan Gel Patch by Orthogonal Design[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(9):1299-1302. |
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| 正交设计优选化瘀散凝胶贴膏基质配方 |
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黄雍,文敏,杨磊,戴冰,李玉星
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Hunanzhongyiyaodaxuediyifushuyiyuan,湖南中医药大学第一附属医院,Hunanzhongyiyaodaxuediyifushuyiyuan,湖南中医药大学第一附属医院,湖南中医药大学
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| 摘要: |
| 目的 优选化瘀散凝胶贴膏基质配方制备工艺的最佳条件。方法 采用正交设计试验，以凝胶贴膏的初黏力、持黏力、剥离强度及追随性为考察指标，对聚丙烯酸钠、明胶、甘油和丙二醇的用量进行优选，确定基质中不同辅料的最佳配比。结果 优选出化瘀散凝胶贴膏最佳基质处方配比为聚丙烯酸钠∶明胶∶甘油∶丙二醇=4∶3∶3∶2。结论 以最优处方基质配比制备的凝胶贴膏，表面平整光滑，具有良好的黏附性和保湿性。 |
| 关键词: 化瘀散 凝胶贴膏 正交设计法 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.09.006 |
| 分类号:R944 |
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| Study on Optimizing Matrix Formulation of Huayusan Gel Patch by Orthogonal Design |
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HuangYong,WenMin,YangLei,DaiBing and LiYuXing
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The First Hospital of Hunan University of Chinese Medicine,The First Hospital of Hunan University of Chinese Medicine,The First Hospital of Hunan University of Chinese Medicine,The First Hospital of Hunan University of Chinese Medicine,Hunan University of Chinese Medicine
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| Abstract: |
| OBJECTIVE To optimize preparation technology of matrix formulation of Huayusan gel patch. METHODS The orthogonal experiment was used to adjust the dosage of sodium polyacrylate, gelatin, glycerinum and propylene glycol and determine optimized proportion of different excipients in matrix with temperciance, permanent adhesion, peel strength, tracing ability of gel patch as the indexes. RESULTS The optimized proportion of matrix formulation in Huayusan gel patch was sodium polyacrylate:gelatin:glycerinum:propylene glycol=4:3:3:2. CONCLUSION The best composition of prescription of Huayusan gel patch is selected. The gel patch made by this prescription is glossy smooth, with pretty good adhesive and humectant properties. |
| Key words: Huayusan gel patch orthogonal design method |
