| 引用本文: | 李浩杰,孟令刚,王翠敏,谢亚娟,曹文利.防己茯苓汤配方颗粒对血栓后综合征患者晚期糖基化终末产物的影响[J].中国现代应用药学,2019,36(1):99-102. |
| LI Haojie,MENG Linggang,WANG Cuimin,XIE Yajuan,CAO Wenli.Effect of Fangji Fuling Decoction Prescription Granules on Advanced Glycation End Products of PTS Patients[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(1):99-102. |
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| 防己茯苓汤配方颗粒对血栓后综合征患者晚期糖基化终末产物的影响 |
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李浩杰1, 孟令刚2, 王翠敏1, 谢亚娟1, 曹文利3
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1.石家庄市中医院脉管科, 河北省中药配方颗粒工程技术研究中心, 石家庄 050051;2.高碑店市兴华社区卫生服务站, 河北 高碑店 074000;3.河北中医学院, 河北省中药配方颗粒工程技术研究中心, 石家庄 050091
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| 摘要: |
| 目的 观察防己茯苓汤配方颗粒对血栓后综合征（post-thrombotic syndrome，PTS）患者临床表现和晚期糖基化终末产物（advanced glycation end products，AGEs）的影响。方法 选取60例PTS患者，按1：1随机数字表法分为试验组和对照组，每组30例。2组患者均给予常规治疗，不行球囊扩张等手术介入治疗，仅服用阿司匹林抗凝药及穿戴医用弹力袜。试验组在此基础上口服防己茯苓汤配方颗粒，每日1剂，bid，分早晚温服；对照组在常规基础治疗上口服脉络疏通丸12 g，tid。比较2组患者治疗前、后病情分级评分及静脉血AGEs水平的变化。结果 治疗后试验组病情分级判定标准评分较治疗前及治疗后对照组均明显降低，差异具有统计学意义（P<0.05），而对照组治疗前、后病情分级判定标准评分差异无统计学意义。试验组Villalta评分及血清AGEs水平均较治疗前及同时间段对照组明显改善（P<0.05），而对照组血清AGEs治疗前后无统计学差异（P>0.05）。试验组出现呕吐症状2例，发生率6.67%，对照组有3例患者出现腹胀，发生率13.33%。结论 防己茯苓汤可以改善PTS患者临床表现，减少AGEs的生成，延缓PTS的发生。 |
| 关键词: 防己茯苓汤配方颗粒 血栓后综合征 晚期糖基化终末产物 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.01.020 |
| 分类号:R285.6 |
| 基金项目:河北省中医药管理局2017年度中医药类科研课题（2017118） |
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| Effect of Fangji Fuling Decoction Prescription Granules on Advanced Glycation End Products of PTS Patients |
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LI Haojie1, MENG Linggang2, WANG Cuimin1, XIE Yajuan1, CAO Wenli3
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1.Department of Pulse Tube, Shijiazhuang Chinese Medicine Hospital, Hebei Engineering Research Center for Chinese Medical Granule, Shijiazhuang 050051, China;2.Gaobeidian Xinghua Community Health Service Station, Gaobeidian 074000, China;3.Hebei College of Traditional Chinese Medicine, Hebei Engineering Research Center for Chinese Medical Granule, Shijiazhuang 050091, China
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| Abstract: |
| OBJECTIVE To observe the effect of formula granule of Fangji Fuling Decoction on the clinical expressions and advanced glycation end products(AGEs) in patients with post-thrombotic syndrome(PTS). METHODS Sixty patients with PTS were randomly divided into experimental group and control group according to 1:1 random number word, 30 cases in each group. Both groups of patients were given conventional treatment, not balloon expansion such interventional surgical of treatment, only oral aspirin such anticoagulants and wearing medical elastic stockings. On the basis of this, the experimental group was given oral Fangji Fuling Decoction prescription granules one dose per day, twice a day at noon and evening; the control group was given 12 g of oral choroid shutong bolus, three times a day. The score of disease status and the level of AGEs in venous blood were compared between the 2 groups before and after treatment. RESULTS The disease grading decision standard scores of the experimental group were lower than before treatment and concurrent control group, the difference was statistically significant(P<0.05).There was no significant difference in the scores of disease grading decision standard before and after treatment in the control group(P>0.05). The Villalta scores and serum AGEs levels in the experimental group were better than before treatment and concurrent control group, the difference was statistically significant(P<0.05). There was no statistical difference in serum AGEs before and after treatment in the control group(P>0.05). There were 2 cases of vomiting in the experimental group, the incidence rate was 6.67%, and 3 cases in the control group occurred abdominal distension, the incidence was 13.33%. CONCLUSION Fangji Fuling Decoction prescription granules can improve the clinical manifestation of PTS patients, reduce the formation of AGEs and delay the occurrence of PTS. |
| Key words: Fangji Fuling Decoction prescription granules post-thrombotic syndrome advanced glycation end products |
