| 引用本文: | 申甚莉,刘建辉.Txnip与胰腺β细胞功能障碍和细胞凋亡[J].中国现代应用药学,2018,35(6):933-936. |
| SHEN Shenli,LIU Jianhui.Advance of Txnip in the Dysfunction and Apoptosis of Pancreatic β Cells[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(6):933-936. |
|
| 摘要: |
| 硫氧还蛋白相互作用蛋白（thioredoxin-interacting protein，Txnip）可通过与硫氧还蛋白（thioredoxin，Trx）相互作用产生二硫键抑制其还原酶活性，在调节细胞氧化还原平衡中起重要作用。近年来，Txnip因为在葡萄糖和脂肪代谢中的重要调节作用，以及与胰腺β细胞功能障碍和细胞凋亡的密切关系而受到广泛关注，Txnip也被认为是2型糖尿病防治的一个新的明星分子。本文拟就国内外有关Txnip与胰腺β细胞功能障碍和细胞凋亡的相关研究进展做一综述。 |
| 关键词: 硫氧还蛋白相互作用蛋白 细胞功能障碍 细胞凋亡 2型糖尿病 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.06.033 |
| 分类号:R284.1 |
| 基金项目:国家自然科学基金项目（81373459）；重庆市基础与前沿研究计划项目（cstc2015jcyjBX0064）；重庆市高校创新团队建设计划项目（CXTDX201601031） |
|
| Advance of Txnip in the Dysfunction and Apoptosis of Pancreatic β Cells |
|
SHEN Shenli, LIU Jianhui
|
|
College of Pharmacy & Bioengineering, Chongqing University of Technology, Chongqing 400054, China
|
| Abstract: |
| Thioredoxin-interacting protein (Txnip) can interacts with thioredoxin (Trx) to inhibit the reducing activity of Trx reductase and it plays an antioxidant effect through disulfide formation with Trx. In recent years, Txnip has been widely concerned due to its regulatory role in glucose and fat metabolism, as well as the close relationship with pancreatic b cells dysfunction and apoptics. Therefore, Txnip has been thought to be a novel therapeutic target for the treatment of type 2 diabetes mellitus (T2DM). Here, we will try to summarize current researches about the roles of Txnip on the development of T2DM, especial for the dysfunction and cellular apoptosis of pancreatic β cells. |
| Key words: thioredoxin-interacting protein (Txnip) cell dysfunction cell apoptosis type 2 diabetes mellitus (T2DM) |
