| 引用本文: | 杨诗婷,王晓倩,廖广辉.金丝桃苷的药理作用机制研究进展[J].中国现代应用药学,2018,35(6):947-951. |
| YANG Shiting,WANG Xiaoqian,LIAO Guanghui.Advances in Pharmacological Effects of Hyperoside[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(6):947-951. |
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| 摘要: |
| 目的 对金丝桃苷抗肿瘤、抗氧化等多种药理作用机制进行综述，为金丝桃苷的进一步研究、寻找潜在治疗靶点与新药开发提供思路，为临床合理用药提供依据。方法 通过大量查阅金丝桃苷相关书籍与资料，总结归纳金丝桃苷抗肿瘤、抗氧化等作用机制。结果 金丝桃苷是一种重要的天然产物，广泛分布于各种植物中的果实与全草中。近年来研究发现金丝桃苷对肿瘤细胞生长具有明显的抑制作用，且能降低脑组织内的活性氧含量，发挥抗氧化作用；此外，金丝桃苷还具有良好的抗抑郁、保护心/脑缺血、保肝、免疫调节等作用。结论 金丝桃苷拥有抗肿瘤、抗氧化等多种作用及较为明确的作用机制，具有广阔的发展空间。 |
| 关键词: 金丝桃苷 抗肿瘤 抗氧化 作用机制 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.06.036 |
| 分类号:R284.1 |
| 基金项目:浙江省重点科技创新团队自主设计项目（2010R50044-15） |
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| Advances in Pharmacological Effects of Hyperoside |
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YANG Shiting, WANG Xiaoqian, LIAO Guanghui
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College of Pharmaceutical Science, Zhejiang University of Traditional Chinese Medicine, Hangzhou, 311400
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| Abstract: |
| OBJECTIVE To review the pharmacological mechanism of hyperoside in anti-tumor and antioxidant, provide ideas for futher study of hyperoside finding out potential therapeutic targets and developing, so then to provide evidences for rational drug use in clinical. METHODS Through a large number of books and materials on hyperoside were reviewed to summarize its anti-tumor and antioxidant mechanisms etc. Summed up the hypericin anti-tumor mechanism and antioxidant effects. RESULTS Hypericin was an important natural product which widely distributed in the fruit of variety plants and the whole herbs. In recent years, it had been found that hyperoside could inhibit the growth of tumor cells, reduce the content of ROS in brain tissue and play an antioxidant role. In addition, hyperoside also had good performance in other aspects, such as antidepressant, heart/cerebral ischemia protection, liver preservation, immune regulation and so on. CONCLUSION Hyperin has a variety effects of anti-tumor, antioxidation etc, and its mechanism of action is clear. It has a broad development space. |
| Key words: hyperoside anti-tumor antioxidant mechanism of action |
