| 引用本文: | 王霞,朱敏霞,韩峰.外泌体在脑卒中病理过程中的作用及机制研究[J].中国现代应用药学,2018,35(7):1095-1101. |
| WANG Xia,ZHU Minxia,HAN Feng.Roles of Exosomes in the Pathological Process of Stroke[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(7):1095-1101. |
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| 摘要: |
| 外泌体是直径30~120 nm的细胞外脂双层囊泡。作为运输信号分子的载体，外泌体能够促使神经血管单元内细胞间通讯，这一功能主要与脑卒中发病后神经元、星形胶质细胞和内皮细胞损伤病理情况有关。外泌体介导神经元病理机制包括：调节神经元发生，促进神经元重塑，适应应激条件以及抑制免疫反应；调节星形胶质细胞的生长，维护血管内皮完整性等。根据外泌体的特性及其作用机制，近年来将外泌体作为生物标志物以及作为药物载体用以诊断或治疗脑卒中的研究不断增加。本文对外泌体在脑卒中发生、发展病理过程中的作用机制和应用进行综述。 |
| 关键词: 外泌体 脑卒中 神经血管单元 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.07.034 |
| 分类号:R966 |
| 基金项目: |
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| Roles of Exosomes in the Pathological Process of Stroke |
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WANG Xia, ZHU Minxia, HAN Feng
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College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China
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| Abstract: |
| Exosomes are lipid-dilayered extracellular vesicles in diameter of 30 to 120 nm. As the transporting carriers of signaling molecules, exosomes promote the exchange of signals among neurons, glial cells and vascular endothelial cells, which is tightly associated with the pathology statues of neurons and blood-brain barrier after onset of stroke. The pathology mechanisms mediated by exosomes include the regulation of neurogenesis, the enhancement of neuronal remodeling, the adaptation to stress and inhibition of immune response; besides, exosomes regulate the growth of astrocytes and the protection of vascular endothelial integrity. Accumulated evidences shown that exosomes as a novel biomarkers and drug carriers for clinical diagnosis or stroke therapy. In this paper, the role of exosomes in brain ischemia is reviewed. |
| Key words: exosomes stroke neurovascular unit |
