| 引用本文: | 金辉,周子晔,王陈翔,戴歌心.替比夫定引起的严重不良反应分析[J].中国现代应用药学,2018,35(8):1245-1247. |
| JIN Hui,ZHOU Ziye,WANG Chenxiang,DAI Gexin.Serious Adverse Reactions Induced by Telbivudine[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(8):1245-1247. |
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| 摘要: |
| 目的 分析替比夫定引起的严重不良反应，为临床合理应用提供参考。方法 检索中国知网、万方和维普全文数据库，就替比夫定引起的严重不良反应进行收集、统计和分析。结果 共收集替比夫定不良反应1 012例，其中严重不良反应42例，对涉及患者的一般情况、联合用药、临床表现、实验室检查、处置和转归等资料进行分析，男性41例，5例死亡，均为横纹肌溶解导致。结论 临床使用替比夫定应加强监测，避免出现高死亡率的严重不良反应。 |
| 关键词: 替比夫定 严重不良反应 横纹肌溶解 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.08.028 |
| 分类号:R969.4 |
| 基金项目: |
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| Serious Adverse Reactions Induced by Telbivudine |
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JIN Hui,ZHOU Zi-ye,WANG Chen-xiang and DAI Ge-xin
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The First Affiliated Hospital of Wenzhou Medical College,The First Affiliated Hospital of Wenzhou Medical College,The First Affiliated Hospital of Wenzhou Medical College,The First Affiliated Hospital of Wenzhou Medical College
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| Abstract: |
| OBJECTIVE To analyze the serious adverse reactions caused by telbivudine to provide a reference for clinical use of telbivudine. METHODS Search the database include CNKI, Wan Fang and VIP information, collect the serious adverse reactions caused by telbivudine, analyze the statistics. RESULTS Collected 1 012 cases of adverse reactions of telbivudine, 42 cases of them were serious. The general information, combined medication, clinical symptoms, laboratory tests results, treatments, and prognosis in patients were analyzed. There were 41 male cases, in which 5 cases of death caused by rhabdomyolysis. CONCLUSION It should be strengthened the monitoring of the clinical use of telbivudine, avoid serious adverse reactions which is high mortality. |
| Key words: telbivudine serious adverse reactions rhabdomyolysis |
