| 引用本文: | 李营营,张吟.腺苷酸活化蛋白激酶促胰岛β细胞凋亡机制的研究进展[J].中国现代应用药学,2018,35(1):143-147. |
| LI Yingying,ZHANG Yin.Research progress on the pro-apoptotic mechanims of AMP-activated Protein Kinase in Islet Beta Cells[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(1):143-147. |
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| 摘要: |
| 腺苷酸活化蛋白激酶（AMP-activated protein kinase，AMPK）是调节细胞能量代谢的关键酶。近几年深入研究发现其具有促胰岛β细胞凋亡的作用，可通过线粒体凋亡途径、内质网应激凋亡途径及哺乳动物mTOR通路等诱导细胞凋亡。本文就AMPK促进胰岛β细胞凋亡的作用及可能的机制作一简要综述。 |
| 关键词: 腺苷酸活化蛋白激酶 线粒体 内质网 mTOR 凋亡 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.01.032 |
| 分类号:R963 |
| 基金项目:国家卫生计生委共建科学基金项目（WKJ-FJ-13）；福建省卫生系统中青年骨干人才培养项目（2015-ZQN-ZD-23） |
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| Research progress on the pro-apoptotic mechanims of AMP-activated Protein Kinase in Islet Beta Cells |
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LI Yingying1,2, ZHANG Yin1
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1.Department of Pharmacy, Fujian Medical University Affiliated Second Hospital, Quanzhou 362000, China;2.School of Pharmaceutical Sciences, Fujian Medical University, Fuzhou 350000, China
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| Abstract: |
| AMP-activated protein kinase (AMPK) is a key enzyme in the regulation of cellular energy metabolism. Recent studies have also found that AMPK may promote apoptosis of islet beta cells. Studies have found that it can induce apoptosis by means of mitochondrial apoptosis pathway, endoplasmic reticulum stress apoptosis pathway and mTOR pathway. The pro-apoptotic effect and passible mechanims of AMPK in islet beta cells have been reviewed in this paper. |
| Key words: AMPK mitochondria endoplasmic reticulum mTOR apoptosis |
