| 引用本文: | 莫国栋,林丽,邱玉婷,何隽灵,万君晗.D-最优混料设计优化复方醋酸曲安奈德乳膏[J].中国现代应用药学,2017,34(10):1409-1412. |
| MO Guodong,LIN Li,QIU Yuting,HE Junling,WAN Junhan.Optimization of Compound Triamcinolone Acetonide Acetate Cream by D-optimal Mixture Design[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(10):1409-1412. |
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| 摘要: |
| 目的 优化乳膏基质的组成，以期得到外观、使用性和稳定性俱佳的复方醋酸曲安奈德乳膏。方法 以离心稳定性、耐寒稳定性、耐热稳定性、粒度、延展性、外观以及清洗性等作为指标，采用D-最优混料设计法确定乳膏基质的组成。结果 最佳复方醋酸曲安奈德乳膏的基质组成：硬脂酸8.3 g，单甘脂7.6 g，白凡士林9.5 g，液体石蜡8.1 g，十二烷基硫酸钠1.1 g，甘油7.5 g，水57 g。结论 按此处方制备的复方醋酸曲安奈德乳膏稳定性好、易涂布、易清洗，外观洁白有光泽。 |
| 关键词: 醋酸曲安奈德 D-最优混料设计 乳膏基质 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.10.010 |
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| Optimization of Compound Triamcinolone Acetonide Acetate Cream by D-optimal Mixture Design |
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MO Guodong1, LIN Li1, QIU Yuting1, HE Junling1, WAN Junhan2
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1.The Second People's Hospital of Zhongshan City, Zhongshan 528445, China;2.School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
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| Abstract: |
| OBJECTIVE To optimize the composition of cream matrix, in order to get the best Compound Triamcinolone Acetonide Acetate cream with good appearance, good usability and good stability. METHODS The composition of the Compound Triamcinolone Acetonide Acetate cream was determined by using D-optimal mixture design method, which was based on the centrifugal stability, cold stability, heat stability, particle size, ductility, appearance and cleaning. RESULTS The best prescription of Compound Triamcinolone Acetonide cream was:stearic acid 8.3 g, glycerol monostearate 7.6 g, white vaseline 9.5 g, liquid paraffin 8.1 g, twelve alkyl sodium sulfate 1.1 g, glycerol 7.5 g and water 57 g. CONCLUSION The Triamcinolone Acetonide Acetate cream made according to the compound prescription preparation have good stability, and it is easy coating. |
| Key words: triamcinolone acetonide acetate D-optimal mixture design cream matrix |
