| 引用本文: | 竺佳,钱莺.乳酸菌阴道胶囊联合抗真菌栓剂序贯给药治疗妊娠期外阴阴道假丝酵母菌病疗效及安全性的Meta分析[J].中国现代应用药学,2017,34(12):1759-1764. |
| ZHU Jia,QIAN Ying.Meta-analysis of the Efficacy and safety of Lacidophilin Vaginal Capsules Combined with Antifungal Suppositories in Sequential Treatment of Vulvovaginal Candidiasis During Pregnancy[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(12):1759-1764. |
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| 摘要: |
| 目的 用meta分析评价乳酸菌阴道胶囊联合抗真菌栓剂序贯给药治疗妊娠期外阴阴道假丝酵母菌病疗效及安全性。方法 计算机检索PubMed、EMbase、Cochrane Libraries、CNKI、万方和维普数据库（各数据库检索时间均从创建至2016年12月），收集相关文献。根据纳入和排除标准筛选并提取资料，采用RevMan 5.2软件进行meta分析。结果 共纳入15项研究，2 522例患者。Meta分析结果显示：乳酸菌阴道胶囊联合抗真菌栓剂试验组的治愈率高于单用抗真菌栓剂对照组，2组相比总治愈率具有统计学差异（P<0.000 01）；乳酸菌阴道胶囊联合抗真菌栓剂试验组的复发率低于单用抗真菌栓对照组，2组相比总复发率具有统计学差异（P<0.000 01）；乳酸菌阴道胶囊联合抗真菌栓试验组的不良反应发生率和单用抗真菌栓剂对照组接近，2组相比总不良反应发生率不具有统计学差异（P=0.68）。结论 基于现有临床证据，乳酸菌阴道胶囊联合抗真菌栓剂治疗妊娠期外阴阴道假丝酵母菌病比单用抗真菌栓剂的疗效好，且复发率低，安全性好。 |
| 关键词: 乳酸菌阴道胶囊 妊娠期 外阴阴道假丝酵母菌病 疗效 安全性 Meta分析 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.12.026 |
| 分类号:R969.4 |
| 基金项目: |
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| Meta-analysis of the Efficacy and safety of Lacidophilin Vaginal Capsules Combined with Antifungal Suppositories in Sequential Treatment of Vulvovaginal Candidiasis During Pregnancy |
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ZHU Jia1, QIAN Ying2
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1.Hangzhou Third People's Hospital, Hangzhou 310009, China;2.Women's Hospital, School of Medicine Zhejiang University, Hangzhou 310006, China
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| Abstract: |
| OBJECTIVE To evaluate the efficacy and safety of Lacidophilin Vaginal capsules combined with antifungal suppositories in sequential treatment of vulvovaginal candidiasis during pregnancy by meta-analysis. METHODS PubMed, EMbase, Cochrane libraries, CNKI, Wanfang and VIP were searched to collect pertinent references(from their inception to December, 2016). Data were extracted and evaluated by two reviewers independently with a designed extraction form. The RevMan 5.2 software was used to carry out meta analysis. RESULTS A total of 15 studies involving 2 522 patients were included. The results of meta-analysis indicated that the cure rate of Lacidophilin Vaginal capsules combined with antifungal suppositories was significantly higher than that of antifungal suppositories(P<0.000 01). The recurrence rate of Lacidophilin Vaginal capsules combined with antifungal suppositories significantly decreased than that of antifungal suppositories (P<0.000 01). There was no significant differences between the adverse drug reaction(ADR) occurrence of Lacidophilin Vaginal capsules combined with antifungal suppositories and antifungal suppositories (P=0.68). CONCLUSION Lacidophilin Vaginal capsules combined with antifungal suppositories in the treatment of vulvovaginal candidiasis during pregnancy is more effective than antifungal suppositories, with lower recurrence rate. |
| Key words: Lacidophilin Vaginal capsules pregnancy vulvovaginal candidiasis efficacy safety meta-analysis |
