UHPLC-Q-TOF-MS测定男性外用壮阳类喷剂中非法添加盐酸丁卡因

邹耀华; 刘宇文; 郑娟

引用本文:	邹耀华,刘宇文,郑娟.UHPLC-Q-TOF-MS测定男性外用壮阳类喷剂中非法添加盐酸丁卡因[J].中国现代应用药学,2017,34(9):1282-1285.
	ZOU Yaohua,LIU Yuwen,ZHENG Juan.Determination of Tetracaine Hydrochloride Which Illegal Added in Male External Products by UHPLC-Q-TOF-MS[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(9):1282-1285.

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UHPLC-Q-TOF-MS测定男性外用壮阳类喷剂中非法添加盐酸丁卡因
邹耀华, 刘宇文, 郑娟
杭州市食品药品检验研究院, 杭州 310015

摘要:

目的建立超高效液相色谱-串联四极杆飞行时间质谱法测定男性外用壮阳喷剂中非法添加盐酸丁卡因的检测方法。方法样品采用C₁₈色谱柱分离，以0.05%甲酸水溶液和乙腈梯度洗脱，采用飞行时间质谱（TOF）和选择离子监测（Target MS/MS）模式检测。结果经对照品确认，样品中检测出盐酸丁卡因。结论本方法可以用于快速鉴定男性外用壮阳类喷剂中非法添加盐酸丁卡因的检测。

关键词: 超高效液相色谱-串联四极杆飞行时间质谱法保健品非法添加盐酸丁卡因

DOI：10.13748/j.cnki.issn1007-7693.2017.09.014

分类号:R917

基金项目:

Determination of Tetracaine Hydrochloride Which Illegal Added in Male External Products by UHPLC-Q-TOF-MS

ZOU Yaohua, LIU Yuwen, ZHENG Juan

Hangzhou Institute for Food and Drug Control, Hangzhou 310015, China

Abstract:

OBJECTIVE To establish a high performance liquid chromatography-quadrupole time of flight mass spectrometry (UHPLC-Q-TOF-MS) method for detection of tetracaine hydrochloride which illegal added in male external products. METHODS Samples were separated by C₁₈ chromatographic column, mobile phase was 0.05% formic acid solution-acetonitrile with gradient elution, TOF and Target MS/MS scanning mode was adopted. RESULTS Confirmed by standard, tetracaine hydrochloride were detected in samples. CONCLUSION The method can be used for rapid identification tetracaine hydrochloride illegally added in male external products.

Key words: UHPLC-Q-TOF-MS health food illegal added tetracaine hydrochloride